Tumor Morphology and Microenvironment

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Ana Félix

Principal Investigator



Campus IPO
Instituto Português de Oncologia de Lisboa Francisco Gentil
Serviço de Anatomia Patológica
Rua Prof. Lima Basto
1099-023 - Lisboa – Portugal

Phone: (+351) 217 200 475
Fax: (+351) 217 229 825
E-mail: ana.felix(at)nms.unl.pt

Main interests

The main aim of our group is to analyse morphological patterns of disease with particular reference to tumor microenvironment, using human cancers.

Research Areas

Cervical cancer: Our aim is to study biological agents as initiators of carcinogenesis and tumor promotion by extracellular matrix components as a means of identifying new prognostic molecular markers and therapeutic targets.
Tumor microenvironment: Role of extracellular matrix components and cell signaling molecules in tumor progression.
Metabolism: Role of a microenvironment rich in lactate in squamous cell carcinoma and adenocarcinoma progression.
Ovarian cancer: Cell alterations due to exposure to HDACs inhibitors.


- "Infecção pelo Vírus Papiloma Humano e cancerigénese do colo do útero- factores biológicos na transformação e progressão neoplásicas" Fundação Calouste Gulbenkian

- “Saúde e Ambiente” in 2005

- "Cell and molecular alterations in ovarian cancer cells induced by vorinostat therapy, identification of biomarkers for therapy response", Departamento de Anatomia Patológica, FCM-CEDOC-UNL, financiado pelo CEDOC

proj ovario

- "Unravelling the role of JAK-STAT pathway inhibition in Solid Neoplasia and the impact of p53 mutational status", IPOLFG/CEDOC

- Ovarian cancer a suitable model to define metabolic profile as a tool to predict chemoresistance. CEDOC/IPOLFG/IBET

proj terry fox

- Molecular mechanisms of cell migration and invasion: developing a new strategy to impair tumor progression, CEDOC/IPOLFG

- Biomarkers and new therapeutic targets in cervical invasive carcinoma - 2014 Terry Fox, financiado pela Liga Portuguesa Contra o Cancro

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neopl leiomioma actin  b11 10156 4-201_125

- IDIBELL, Institut Català d’Oncologia-Catalan Institute of Oncology, Spain.
Centro de Investigación Biomédica en Red de Epidemiologia y Salud Pública, Barcelona, Spain.

- António Almeida, Epigenetics and Transcriptional Regulation Lab – IPOLFG/CEDOC

- Luis Gafeira Gonçalves, Cell Physiology and NMR Lab - ITQB

- Eric Lam, Molecular Oncology - Imperial College London, United Kingdom

Team photos