2021

Conde J. & GBD 2019 Under-5 Mortality Collaborators. Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019. Lancet. 2021 Aug 17:S0140-6736(21)01207-1. doi: 10.1016/S0140-6736(21)01207-1. Epub ahead of print. PMID: 34416195.

Perdigão C, Barata MA, Burrinha T, Almeida CG. Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling. J Biol Chem. 2021 Aug 7:101056. doi: 10.1016/j.jbc.2021.101056. Epub ahead of print. PMID: 34375641.

Sousa L, Guarda M, Meneses MJ, Macedo MP, Vicente Miranda H. Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases. J Pathol. 2021 Aug 16. doi: 10.1002/path.5777. Epub ahead of print. PMID: 34396529.

Nunes SC, Ramos C, Santos I, Mendes C, Silva F, Vicente JB, Pereira SA, Félix A, Gonçalves LG, Serpa J. Cysteine Boosts Fitness Under Hypoxia-Mimicked Conditions in Ovarian Cancer by Metabolic Reprogramming. Frontiers in Cell and Developmental Biology. 2021 (9) 2107. doi: 10.3389/fcell.2021.72241.

Alenquer M, Ferreira F, Lousa D, Valério M, Medina-Lopes M, Bergman ML, Gonçalves J, Demengeot J, Leite RB, Lilue J, Ning Z, Penha-Gonçalves C, Soares H, Soares CM, Amorim MJ. Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies. PLoS Pathog. 2021 Aug 5;17(8):e1009772. doi: 10.1371/journal.ppat.1009772. PMID: 34352039

Escrevente C, Falcão AS, Hall MJ, Lopes-da-Silva M, Antas P, Mesquita MM, Ferreira IS, Cardoso MH, Oliveira D, Fradinho AC, Ciossek T, Nicklin P, Futter CE, Tenreiro S, Seabra MC. Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction. Invest Ophthalmol Vis Sci. 2021 Jul 1;62(9):39. doi: 10.1167/iovs.62.9.39. PMID: 34313720.

Talebian S, Rodrigues T, das Neves J, Sarmento B, Langer R, Conde J. Facts and Figures on Materials Science and Nanotechnology Progress and Investment. ACS Nano. 2021 Jul 28. doi: 10.1021/acsnano.1c03992. Epub ahead of print. PMID: 34320802.

Escrevente C, Bento-Lopes L, Ramalho JS, Barral DC. Rab11 is required for lysosome exocytosis through the interaction with Rab3a, Sec15 and GRAB. J Cell Sci. 2021 Jun 1;134(11):jcs246694. doi: 10.1242/jcs.246694

Mendes BB, Sousa DP, Conniot J, Conde J. Nanomedicine-based strategies to target and modulate the tumor microenvironment. Trends in Cancer., 03 June 2021. doi: 10.1016/j.trecan.2021.05.001

Silva NV, Carregosa D, Gonçalves C, Vieira OV, Santos CN, Jacinto A, Crespo CL. Dietary Cholesterol-Based Intestinal Inflammation Assay for Improving Drug-Discovery on Inflammatory Bowel Diseases. Front. Cell Dev. Biol., 03 June 2021. doi: 10.3389/fcell.2021.674749

Rosado-Ramos R, Godinho-Pereira J, Marques D, Figueira I, Outeiro TF, Menezes R, Santos CN. Small Molecule Fisetin Modulates Alpha–Synuclein Aggregation. Molecules 2021, 26(11), 3353; 02 June 2021. doi: 10.3390/molecules26113353

Burrinha T, Martinsson I, Gomes R, Terrasso AP, Gouras GK, Almeida CG. Upregulation of APP endocytosis by neuronal aging drives amyloid-dependent synapse loss. J Cell Sci 1 May 2021; 134 (9): jcs255752. doi: 10.1242/jcs.255752

Santos-Pereira A, Triunfante V, Araújo PMM, Martins J, Soares H, López EP, Souto B, Osório NS (2021). Nationwide study of drug resistance mutations in HIV-1 infected individuals under antiretroviral therapy in Brazil. International Journal of Molecular Sciences. Int. J. Mol. Sci. 2021, 22(10), 5304; doi: 10.3390/ijms22105304.

Gonçalves J, Juliano AM, Charepe N, Alenquer M, Athayde D, Ferreira F, Archer M, Amorim MJ, Serrano F, Soares H. Non-neutralizing secretory IgA and T cells targeting SARS-CoV-2 spike protein are transferred to the breastmilk upon BNT162b2 vaccination. medRxiv May 04, 2021. preprint doi: https://doi.org/10.1101/2021.05.03.21256416

Alenquer M, Ferreira F, Lousa D, Valério M, Medina-Lopes M, Bergman M L, Gonçalves J, Demengeot, Leite R B, Lilue J, Ning Z, Penha-Gonçalves C, Soares H, Soares C M, Amorim M J. Amino acids 484 and 494 of SARS-CoV-2 spike are hotspots of immune evasion affecting antibody but not ACE2 binding. bioRxiv Apr 22, 2021. preprint doi: https://doi.org/10.1101/2021.04.22.441007

Marques, ARA; Ramos, C; Machado-Oliveira, G; Vieira, OV. Lysosome (Dys)function in Atherosclerosis—A Big Weight on the Shoulders of a Small Organelle. Frontiers in Cell and Developmental Biology Vol. 9, 29 March 2021. doi: 10.3389/fcell.2021.658995.

Pkd2 Affects Cilia Length and Impacts LR Flow Dynamics and Dand5. Raquel Jacinto, Pedro Sampaio, Mónica Roxo-Rosa, Sara Pestana, Susana Lopes. Front. Cell Dev. Biol. 9, 624531; DOI: 10.3389/fcell.2021.624531. Published 1 April 2021

Andrade C, Oliveira B, Guatelli S, Martinez P, Simões B, Bispo C, Ferrario C, Bonasoro F, Rino J, Sugni M, Gardner R, Zilhão R and Coelho AV. Characterization of Coelomic Fluid Cell Types in the Starfish Marthasterias glacialis Using a Flow Cytometry/Imaging Combined Approach. Front. Immunol. (2021) 12:641664. doi: 10.3389/fimmu.2021.641664

CiliarMove: new software for evaluating ciliary beat frequency helps find novel mutations by a Portuguese multidisciplinary team on primary ciliary dyskinesia. Pedro Sampaio, Mónica Ferro da Silva, Inês Vale, Mónica Roxo-Rosa, Andreia Pinto, Carolina Constant, Luisa Pereira, Carla M. Quintão, Susana S. Lopes. ERJ Open Res 7: 00792-2020; DOI: 10.1183/23120541.00792-2020 Published 8 February 2021

Unmasking the relevance of hemispheric asymmetries-Break on through (to the other side). Esteves M, Lopes SS, Almeida A, Sousa N, Leite-Almeida H. Prog Neurobiol. 2020 Sep;192:101823. doi: 10.1016/j.pneurobio.2020.101823. Epub 2020 May 17.

Alpuim Costa D, Nobre JG, Batista MV, Ribeiro C, Calle C, Cortes A, Marhold M, Negreiros I, Borralho P, Brito M, Cortes J, Braga SA and Costa L (2021) Human Microbiota and Breast Cancer—Is There Any Relevant Link?—A Literature Review and New Horizons Toward Personalised Medicine. Front. Microbiol. 12:584332. doi: 10.3389/fmicb.2021.584332

Galderisi S, Cicaloni V, Milella MS, Millucci L, Geminiani M, Salvini L, Tinti L, Tinti C, Vieira OV, Alves LS, Crevenna AH, Spiga O, Santucci A. Homogentisic acid induces cytoskeleton and extracellular matrix alteration in alkaptonuric cartilage. J Cell Physiol. 2021 Jan 20. doi: 10.1002/jcp.30284. Online ahead of print.PMID: 33469937

Gregório, M.J., Irving, S., Teixeira, D. et al. The national food and nutrition strategy for the Portuguese COVID-19 response. Eur J Clin Nutr (2021). https://doi.org/10.1038/s41430-020-00818-w

Domingues N, Calado RDA, Brito PH, Matthiesen R, Ramalho J, Soares MLS, Pereira T, Oliveira L, Vicente JR, Wong LH, Cho SM, Simões ICM, Sampaio J, Klose C, Surma MA, Almeida MS, Rodrigues G, Gonçalves PA, Ferreira J, Simons K, Melo e Pinho TMVD, Peden A. Cholesteryl Hemiazelate Induces Lysosome Dysfunction and Exocytosis in Macrophages. bioRXiv 2021 Jan 5. doi:https://doi.org/10.1101/2021.01.05.422575