2020

Meschede IP, Burgoyne T, Tolmachova T, Seabra MC, Futter CE. Chronically shortened rod outer segments accompany photoreceptor cell death in Choroideremia. PLoS One. 2020 Nov 17;15(11):e0242284. doi: 10.1371/journal.pone.0242284. eCollection 2020.
PMID: 33201897

Gross T, Wack G, Syhr KMJ, Tolmachova T, Seabra MC, Geisslinger G, Niederberger E, Schmidtko A, Kallenborn-Gerhardt W. Rab27a Contributes to the Processing of Inflammatory Pain in Mice. Cells. 2020 Jun 18;9(6):1488. doi: 10.3390/cells9061488.
PMID: 3257093

Fernández-Messina L, Rodríguez-Galán A, de Yébenes VG, Gutiérrez-Vázquez C, Tenreiro S, Seabra MC, Ramiro AR, Sánchez-Madrid F. Transfer of extracellular vesicle-microRNA controls germinal center reaction and antibody production. EMBO Rep. 2020 Apr 3;21(4):e48925. doi: 10.15252/embr.201948925. Epub 2020 Feb 19.PMID: 32073750

Moreiras H, Pereira FJC, Neto MV, Bento-Lopes L, Festas TC, Seabra MC, Barral DC. The exocyst is required for melanin exocytosis from melanocytes and transfer to keratinocytes. Pigment Cell Melanoma Res. 2020 Mar;33(2):366-371. doi: 10.1111/pcmr.12840. Epub 2019 Nov 19.
PMID: 31665827.

Raben, A, Vestentoft, PS, Brand‐Miller, J, et al. The PREVIEW intervention study: Results from a 3‐year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes. Diabetes Obes Metab. 2020; 1– 14. https://doi.org/10.1111/dom.14219

Herédia F#, Volonté Y#, Pereirinha J#, Fernandez-Acosta M, Casimiro AP, Belém CP, Viegas F, Tanaka K, Arana M, Cardoso G, Macedo M, Kotowicz M, Prado Spalm F, Dibo MV, Monfardini RD, Torres TT, Mendes CS, Garelli A*, Gontijo AM*. Innate Behavior Sequence Progression by Peptide-Mediated Interorgan Crosstalk. bioRxiv 2020.10.10.334540; doi: https://doi.org/10.1101/2020.10.10.334540. # Equal contribution. * Corresponding authors.

Macedo A, Gontijo AM. The intersectional genetics landscape for humans. Gigascience. 2020 Aug 1;9(8):giaa083. doi: 10.1093/gigascience/giaa083. PMID: 32761099.

J Pinho, C Marcut, R Fonseca. Actin remodeling, the synaptic tag and the maintenance of synaptic plasticity. IUBMB life. 2020. 72 (4), 577-589.

N Madeira, A Drumond, R Fonseca. Temporal Gating of Synaptic Competition in the Amygdala by Cannabinoid Receptor Activation. Cerebral Cortex. 2020. 30 (7), 4064-4075.

Ferreira J, Félix A. Carcinosarcoma (MMMT). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusmmmt0.html. Accessed July 27th, 2020

Medeiros-Fonseca B, et al. HPV16 induces penile intraepithelial neoplasia and squamous cell carcinoma in transgenic mice: first mouse model for HPV-related penile cancer. J Pathol. 2020. 251, 4, 411-419. https://doi.org/10.1002/path.5475

Gil da Costa RM, Neto T, Estêvão D, Moutinho M, Félix A, Medeiros R, Lopes C, Bastos MMSM, Oliveira PA. Ptaquiloside from bracken (Pteridium spp.) promotes oral carcinogenesis initiated by HPV16 in transgenic mice. Food Funct. 2020. 11(4):3298-3305. doi: 10.1039/d0fo00207k

André S, Nunes SP, Silva F, Henrique R, Félix F, Jerónimo C. Analysis of Epigenetic Alterations in Homologous Recombination DNA Repair Genes in Male Breast Cancer. Int J Mol Sci. 2020. 21, 8, 2715.

Bargão Santos P, Lobo J, Félix A, Silva F, Manso RT, Costa JO, Lourenço B, Sequeira JP, Jerónimo C, Patel HHR, Henrique R. The inflammation-related biomarker CXCR7 independently predicts patient outcome after radical prostatectomy. Urol Oncol. 2020 Oct;38(10):794.e17-794.e27. doi: 10.1016/j.urolonc.2020.03.004. Epub 2020 Apr 9.

Mestre VF, Medeiros-Fonseca B, Estêvão D, Casaca F, Silva S, Félix A, Silva F, Colaço B, Seixas F, Bastos MM, Lopes C, Medeiros R, Oliveira PA, Gil da Costa RM. HPV16 is sufficient to induce squamous cell carcinoma specifically in the tongue base in transgenic mice. J Pathol. 2020 May;251(1):4-11. doi: 10.1002/path.5387. Epub 2020 Mar 10.

Esteves G, Ferreira J, Afonso R, Martins C, Zagalo C, Félix A. HDAC Overexpression in a NUT Midline Carcinoma of the Parotid Gland with Exceptional Survival: A Case Report. Head Neck Pathol. 2020 Jan 27. doi: 10.1007/s12105-020-01130-6. Epub ahead of print.

Esteves GF, Félix A. Dermal nerve sheath myxoma. PathologyOutlines.com website http://www.pathologyoutlines.com/topic/softtissuenervesheathmyxoma.html. Accessed January 9th, 2020

Santos PB, Patel H, Henrique R, Félix A. Can epigenetic and inflammatory biomarkers identify clinically aggressive prostate cancer? World J Clin Oncol. 2020 Feb 24;11(2):43-52. doi: 10.5306/wjco.v11.i2.43.

Bennett JA, Ritterhouse LL, Furtado LV, Lastra RR, Pesci A, Newell JM, Burandt E, Kooreman L, Van de Vijver K, Krausz T, Felix A, Zannoni GF, Young RH, Oliva E. Female adnexal tumors of probable Wolffian origin: morphological, immunohistochemical, and molecular analysis of 15 cases. Mod Pathol. 2020 Apr;33(4):734-747. doi: 10.1038/s41379-019-0375-9. Epub 2019 Oct 7.

Lérias S, Esteves S, Silva F, Cunha M, Cochicho D, Martins L, Félix A. CD274 (PD-L1), CDKN2A (p16), TP53, and EGFR immunohistochemical profile in primary, recurrent and metastatic vulvar cancer. Mod Pathol. 2020 May;33(5):893-904. doi: 10.1038/s41379-019-0429-z. Epub 2019 Dec 16.

Cotzia P, Benayed R, Mullaney K, Oliva E, Felix A, Ferreira J, Soslow RA, Antonescu CR, Ladanyi M, Chiang S. Undifferentiated Uterine Sarcomas Represent Under-Recognized High-grade Endometrial Stromal Sarcomas. Am J Surg Pathol. 2019 May;43(5):662-669. doi: 10.1097/PAS.0000000000001215

Hakeem S, Mendonça N, Aspray T, Kingston A, Martin-Ruiz C, Jagger C, Mathers J, Duncan R, Hill TR (2020) The association between 25-hydroxyvitamin D concentration and disability trajectories in very-old adults: The Newcastle 85+ Study. Nutrients 2020, September 9. 12(9), 2742. doi:10.3390/nu12092742.

van Velsen L, Cabrita M, op den Akker H, Brandl L, Isaac J, Suárez M, Gouveia A, Evans N, Dinis de Sousa R, Rodrigues AM, Canhão H, DELA Natura-En Levensverzekeringen NV , Blok M, Alcobia C, Brodbeck J (2020) LEAVES (optimizing the mentaL health and resiliencE of older Adults that haVe lost thEir spouSe via blended, online therapy): Proposal for an Online Service Development and Evaluation. JMIR Res Protoc 2020, September 8. 9(9):e19344. doi: 10.2196/19344.

Perri, G.; Mendonça, N.; Jagger, C.; Walsh, J.; Eastell, R.; Mathers, J.C.; Hill, T.R. (2020) Dietary Selenium Intakes and Musculoskeletal Function in Very Old Adults: Analysis of the Newcastle 85+ Study. Nutrients 2020, July 12. 12(7), 2068. doi: 10.3390.

Unmasking the relevance of hemispheric asymmetries-Break on through (to the other side). Esteves M, Lopes SS, Almeida A, Sousa N, Leite-Almeida H. Prog Neurobiol. 2020 Sep;192:101823. doi: 10.1016/j.pneurobio.2020.101823. Epub 2020 May 17.

Lopes-Coelho F, Silva F, Gouveia-Fernandes S, Martins C, Lopes N, Domingues G, Brito C, Almeida AM, Pereira SA, Serpa J. Monocytes as Endothelial Progenitor Cells (EPCs), Another Brick in the Wall to Disentangle Tumor Angiogenesis. Cells. 2020 Jan 1;9(1):107. doi: 10.3390/cells9010107.

Cruz A, Mota P, Ramos C, Pires RF, Mendes C, Silva JP, Nunes SC, Bonifácio VDB, Serpa J. Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance. Antioxidants (Basel). 2020 Feb 3;9(2):133. doi: 10.3390/antiox9020133.

Hipólito A, Nunes SC, Vicente JB, Serpa J. Cysteine Aminotransferase (CAT): A Pivotal Sponsor in Metabolic Remodeling and an Ally of 3-Mercaptopyruvate Sulfurtransferase (MST) in Cancer. Molecules. 2020 Sep 1;25(17):E3984. doi: 10.3390/molecules25173984.

Serpa J. Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival. Front Oncol. 2020 Jun 23;10:947. doi: 10.3389/fonc.2020.00947. eCollection 2020.

Lopes-Coelho F, Martins F, Serpa J. Endothelial Cells (ECs) Metabolism: A Valuable Piece to Disentangle Cancer Biology. Adv Exp Med Biol. 2020;1219:143-159. doi: 10.1007/978-3-030-34025-4_8.

Nunes SC, Serpa J. Recycling the Interspecific Relations with Epithelial Cells: Bacteria and Cancer Metabolic Symbiosis. Adv Exp Med Biol. 2020;1219:77-91. doi: 10.1007/978-3-030-34025-4_4.

Mendes C, Serpa J. Revisiting lactate dynamics in cancer-a metabolic expertise or an alternative attempt to survive? J Mol Med (Berl). 2020 Aug 22. doi: 10.1007/s00109-020-01965-0. Online ahead of print.

Serpa J. Metabolic Remodeling as a Way of Adapting to Tumor Microenvironment (TME), a Job of Several Holders. Adv Exp Med Biol. 2020;1219:1-34. doi: 10.1007/978-3-030-34025-4_1.

Hipólito A, Mendes C, Serpa J. The Metabolic Remodelling in Lung Cancer and Its Putative Consequence in Therapy Response. Adv Exp Med Biol. 2020;1219:311-333. doi: 10.1007/978-3-030-34025-4_16.

Pite H, Aguiar L, Morello J, Monteiro EC, Alves AC, Bourbon M, Morais-Almeida M. Metabolic Dysfunction and Asthma: Current Perspectives. Journal of Asthma and Allergy Volume 2020:13 Pages 237—247.

Macedo A, Gontijo AM. The intersectional genetics landscape for humans. Gigascience. 2020 Aug 1;9(8):giaa083. doi: 10.1093/gigascience/giaa083. PMID: 32761099

Gonçalves-Bradley DC, Maria ARJ, Ricci-Cabello I, Villanueva G, Fønhus MS, Glenton C, et al. Mobile technologies to support healthcare provider to healthcare provider communication and management of care. Cochrane Database of Systematic Reviews [Internet]. 2020 [cited 2020 Aug 19];(8).

Meschede IP, Ovenden NC, Seabra MC, Futter CE, Votruba M, Cheetham ME, Burgoyne T. Symmetric arrangement of mitochondria:plasma membrane contacts between adjacent photoreceptor cells regulated by Opa1. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15684-15693. doi: 10.1073/pnas.2000304117.

Lopes-Coelho F, Silva F, Gouveia-Fernandes S, Martins C, Lopes N, Domingues G, Brito C, Almeida AM, Pereira SA, Serpa J. Monocytes as Endothelial Progenitor Cells (EPCs), Another Brick in the Wall to Disentangle Tumor Angiogenesis. Cells. 2020 Jan 1;9(1). pii: E107

Morais J, Marques C, Teixeira D, Durão C, Faria A, Brito S, Cardoso M, Macedo I, Pereira E, Tomé T, Calhau C. Extremely preterm neonates have more Lactobacillus in meconium than very preterm neonates - the in utero microbial colonization hypothesis. Gut Microbes. 2020 Jul 13:1-9. doi: 10.1080/19490976.2020.1785804. Online ahead of print. PMID: 32658601

Flores R, Carneiro A, Serra J, Gouveia N, Pereira T, Mendes JM, Coelho PS, Tenreiro S, Seabra MC.Correlation study between mprphology and fundus autofluorescence. Retina. 2020 Jun 26. doi: 10.1097/IAE.0000000000002881. Online ahead of print. PMID: 32604342

Conde J. Above and Beyond Cancer Therapy: Translating Biomaterials into the Clinic. Trends Cancer. 2020 May 16:S2405-8033(20)30138-2. doi: 10.1016/j.trecan.2020.04.008. Online ahead of print. PMID: 32430152

Roulet C, Rozsnyai Z, Jungo KT, A van der Ploeg M, Floriani C, Kurpas D, et al. Managing hypertension in frail oldest-old-The role of guideline use by general practitioners from 29 countries. PLoS ONE. 2020;15(7):e0236064.

Cipriano M, Pinheiro PF, Sequeira CO, Rodrigues JS, Oliveira NG, Antunes AMM, Castro M, Marques MM, Pereira SA, Miranda JP. Nevirapine biotransformation insights: An integrated in vitro approach unveils the biocompetence and glutathiolomic profile of a human hepatocyte-like cell 3d model. Int J Mol Sci. 2020 Jun; 21(11): 3998. doi: 10.3390/ijms21113998

Erny GL, Gomes RA, Santos MSF, Santos L, Neuparth N, Carreiro-Martins P, Marques JG, Guerreiro ACL and Gomes-Alves P. Mining for Peaks in LC-HRMS Datasets Using Finnee − A Case Study with Exhaled Breath Condensates from Healthy, Asthmatic, and COPD Patients. ACS Omega Article ASAP DOI: 10.1021/acsomega.0c01610

Sebastião CS, Neto Z, Jandondo D, Mirandela M, Morais J, Brito M (2020) HIV, Hepatitis B Virus, Hepatitis C Virus, and Syphilis Among Pregnant Women Attending Antenatal Care in Luanda, Angola: Seroprevalence and Risk Factors. 2020 Jun 9. doi: 10.1002/jmv.26148. Online ahead of print

Skarlatou S, Hérent C, Toscano E, Mendes CS, Bouvier J, Zampieri N (2020) Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection. Cell Reports, Jun 9, 31(10):107741

Baptista S, Heleno B, Teixeira A, Taylor KL, Martins C. Comparison of explicit values clarification method (VCM), implicit VCM and no VCM decision aids for men considering prostate cancer screening: protocol of a randomized trial. BMC Medical Informatics and Decision Making. 2020 Apr 29;20(1):78.

Guedes MCE, Arroz MJ, Martins C, Angelo-Dias M, Proença RD, Borrego LM. Regulatory T cells and IL-17A levels in noninfectious uveitis. Graefes Arch Clin Exp Ophthalmol. 2020 Mar 21. doi: 10.1007/s00417-020-04649-0. Epub ahead of print. PMID: 32200408.

Matias J, Gaspar A, Borrego LM, Piedade S, Pires G, Arede C, Sampaio G, Morais Almeida M. Tree Nuts Anaphylaxis in Preschool Age Children. Eur Ann Allergy Clin Immunol. 2020 Jan 8. doi: 10.23822/EurAnnACI.1764-1489.128. Epub ahead of print. PMID: 31912691.

A.Gomes, J.Godinho-Pereira, C.Oudot,C.O.Sequeira, A.Macià ,F.Carvalho, M.J.Motilva, S.A.Pereira, M.Matzapetakis, C.Brenner, C.N.Santos. Berry fruits modulate kidney dysfunction and urine metabolome in Dahl salt-sensitive rats. Free Radical Biology and Medicine Volume 154, July 2020, Pages 119-131. https://doi.org/10.1016/j.freeradbiomed.2020.05.002

Coelho NR, Tomkiewicz C, Correia MJ, Gonçalves-Dias C, Barouki R, Pereira SA, Coumoul X, Monteiro EC. First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia. Pharmacol Res. 2020 May 13:104869. doi: 10.1016/j.phrs.2020.104869.

Ponte C, Khmelinskii N, Teixeira V, Luz K, Peixoto D, Rodrigues M, Luís M, Teixeira L, Sousa S, Madeira N, Aleixo JA, Pedrosa T, Serra S, Campanilho-Marques R, Castelão W, Cordeiro A, Cordeiro I, Fernandes S, Macieira C, Madureira P, Malcata A, Vieira R, Martins F, Sequeira G, Branco JC, Costa L, Patto JV, da Silva JC, Pereira da Silva JA, Afonso C, Canhão H, Santos MJ, Luqmani RA, Fonseca JE (2020) Reuma.pt/vasculitis - the Portuguese vasculitis registry. Orphanet J Rare Dis. 2020 May 5;15(1):110. doi: 10.1186/s13023-020-01381-0.

Mendonça N, Kingston A, Yadegarfar ME, Hanson H, Duncan R, Jagger C, Robinson L (2020). Transitions between frailty states in the very old: the influence of socioeconomic status and multi-morbidity in the Newcastle 85+ cohort study. Age Ageing. 2020 Apr 28. pii: afaa054. doi: 10.1093/ageing/afaa054.

Vieira-Sousa E, Alves P, Rodrigues AM, Teixeira F, Tavares-Costa J, Bernardo A, Pimenta S, Pimentel-Santos FM, Gomes JL, Aguiar R, Pinto P, Videira T, Catita C, Santos H, Borges J, Sequeira G, Ribeiro C, Teixeira L, Ávila-Ribeiro P, Martins FM, Canhão H, McInnes IB, Ribeiro RM, Fonseca JE (2020) GO-DACT: a phase 3b randomised, double-blind, placebo-controlled trial of GOlimumab plus methotrexate (MTX) versus placebo plus MTX in improving DACTylitis in MTX-naive patients with psoriatic arthritis. Ann Rheum Dis. 2020 Apr;79(4):490-498. doi: 10.1136/annrheumdis-2019-216500.

Duarte C, Carvalheiro H, Rodrigues AM, Dias SS, Marques A, Santiago T, Canhão H, Branco JC, da Silva JAP (2020) Correction to: Prevalence of vitamin D deficiency and its predictors in the Portuguese population: a nationwide population-based study. Arch Osteoporos. 2020 Apr 2;15(1):55. doi: 10.1007/s11657-020-00728-1.

Cruz EB, Canhão H, Fernandes R, Caeiro C, Branco JC, Rodrigues AM, Pimentel-Santos F, Gomes LA, Paiva S, Pinto I, Moniz R, Nunes C (2020) Prognostic indicators for poor outcomes in low back pain patients consulted in primary care. PLoS One. 2020 Mar 27;15(3):e0229265. doi: 10.1371/journal.pone.0229265. eCollection 2020.

Manuel Sánchez-Maldonado J, Martínez-Bueno M, Canhão H, Ter Horst R, Muñoz-Peña S, Moñiz-Díez A, Rodríguez-Ramos A, Escudero A, Sorensen SB, Hetland ML, Ferrer MA, Glintborg B, Filipescu I, Pérez-Pampin E, Conesa-Zamora P, García A, den Broeder A, De Vita S, Hove Jacobsen SE, Collantes E, Quartuccio L, Netea MG, Li Y, Fonseca JE, Jurado M, López-Nevot MÁ, Coenen MJH, Andersen V, Cáliz R, Sainz J. (2020) NFKB2 polymorphisms associate with the risk of developing rheumatoid arthritis and response to TNF inhibitors: Results from the REPAIR consortium. Sci Rep. 2020 Mar 9;10(1):4316. doi: 10.1038/s41598-020-61331-5.

Duarte C , Carvalheiro H , Rodrigues AM , Dias SS , Marques A , Santiago T , Canhão H, Branco JC , da Silva JAP (2020) Prevalence of vitamin D deficiency and its predictors in the Portuguese population: a nationwide population-based study. Arch Osteoporos

Laires PA, Serrano-Alarcón M, Canhão H, Perelman J (2020) Multimorbidity and intention to retire: a cross-sectional study on 14 European countries. Int J Public Health. 2020 Mar;65(2):187-195. doi: 10.1007/s00038-019-01322-0. Epub 2019 Dec 20.

Pires DADF, Brazete Cruz EJC, Canhão HCM, Nunes CDRD (2020) The role of pain and disability changes after physiotherapy treatment on global perception of improvement in patients with chronic low back pain. Musculoskelet Sci Pract. 2020 Feb 28;47:102139. d

Casalou, C., Ferreira, A. & Barral, D. C. The Role of ARF Family Proteins and Their Regulators and Effectors in Cancer Progression: A Therapeutic Perspective. 21 Apr 2020, In: Frontiers in Cell and Developmental Biology. 8, 217.

Mendes Nunes J, Feliz J, Barroca M, Vaz de Almeida C. CADERNOS TÉCNICOS 03 - SAÚDE E ENVELHECIMENTO (DIGITAL). [Internet].

R.S Araújo, M.S. Silva, D.F. Santos, G.A. Silva. Dysregulation of trophic factors contributes to diabetic retinopathy in the Ins2Akita mouse. Experimental Eye Research. Vol 194. May 2020, 108027.

Shinn C, Salgado R, Rodrigues D. Programa Nacional para a Promoção da Atividade Física: o caso de Portugal. Ciênc saúde coletiva. 2020 Apr;25(4):1339–48.

Pisco L, Pinto LF. De Alma-Ata a Astana: o percurso dos Cuidados de Saúde Primários em Portugal,1978-2018 e a génese da Medicina Familiar. Ciênc saúde coletiva. 2020 Apr;25(4):1197–204.

Pinto LF, Soranz D, Ponka D, Pisco LA, Hartz ZM, Pinto LF, et al. 40 anos de Alma-Ata: desafios da Atenção Primária à Saúde no Brasil e no mundo. Ciênc saúde coletiva. 2020 Apr;25(4):1178–1178.

Malmqvist J, Siersma V, Thorsen H, Heleno B, Rasmussen JF, Brodersen J. Did psychosocial status, sociodemographics and smoking status affect non-attendance in control participants in the Danish Lung Cancer Screening Trial? A nested observational study. BMJ Open. 2020 Feb;10(2):e030871.

Brodersen J, Voss T, Martiny F, Siersma V, Barratt A, Heleno B.Overdiagnosis of lung cancer with low-dose computed tomography screening: meta-analysis of the randomised clinical trials. Breathe (Sheff). 2020 Mar;16(1):200013.

Baptista S, Heleno B, Pinto M, Guimarães B, China D, Ramos JP, et al.Translation and cultural adaptation of a prostate cancer screening decision aid: a qualitative study in Portugal. BMJ Open. 2020 Mar 1;10(3):e034384.

Silva Z, Ferro T, Almeida D, Soares H, Ferreira JA, Deschepper FM, Hensbergen PJ, Pirro M, van Vliet SJ, Springer S, Videira PA (2020) MHC class I stability is modulated by cell surface sialylation in human dendritic cells. Pharmaceutics. In press

Silva-Rodrigues JF, Patrício-Rodrigues CF, de Sousa-Xavier V, Augusto PM, Fernandes AC, Farinho AR, Martins JP, Teodoro RO. Peripheral axonal ensheathment is regulated by Ral GTPase and the exocyst complex. Development 2020 : dev.174540 doi: 10.1242/dev.174540 Published 22 January 2020

Lopes-Coelho F, Silva F, Gouveia-Fernandes S, Martins C, Lopes N, Domingues G, Brito C, Almeida AM, Pereira SA, Serpa J. Monocytes as Endothelial Progenitor Cells (EPCs), Another Brick in the Wall to Disentangle Tumor Angiogenesis. Cells 2020, 9(1), 107; doi: 10.3390/cells9010107