‘The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism’

The paper ‘The Synthetic Cannabinoid JWH-018 Modulates Saccharomyces Cerevisiae Energetic Metabolism’ by Carla Ferreira, Joana Couceiro, Carlos Família, Carolina Jardim, Pedro Antas, Cláudia N Santos, Tiago F Outeiro, Sandra Tenreiro and Alexandre Quintas has been selected as the Editor’s Choice article for Issue 19-5 of FEMS Yeast Research.

This research project tried to understand the impact of JWH-018 - the first novel psychoactive substance found in the recreational drug Marketplace - at a molecular and cellular level by using Saccharomyces cerevisiae as a model.

The results showed an increase in yeast growth rate in the presence of this synthetic cannabinoid due to an enhancement in the glycolytic flux at expense of a decrease in pentose phosphate pathway, judging by 2D-Gel proteomic analysis, qRT-PCR experiments and ATP measurements.

Full article available here.

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