Proteins important in the molecular basis of Tuberculosis infection were identified by a group of scientists of CEDOC

A study performed by Marisa Encarnação and Otília Vieira, from the Lysosomes in Chronic Human Pathologies and Infections Lab and Lilia Espada and Duarte Barral, from the Membrane Traffic in Infection and Disease Lab, in collaboration with scientists of Universidade de Coimbra and Harvard Medical School, identified two proteins, termed Rab3a and Slp4-a, that play a crucial role lysosome positioning and plasma membrane repair in the context of Mycobacterium tuberculosis infection.
This finding is of great importance because discovering these new players contributes to unravel various processes in the human body, such as fulminating tuberculosis and muscle cell repair after physical exercise.

Article is entitled "Rab3a-dependent complex essencial for lysosome positioning and plasma membrane repair" (full article here).

This article featured a Spotlight on Journal of Cell Biology and more recently has been recommended in F1000Prime as being of speacial significance in its field by F1000 Faculty Member Michael Roth, from University of Texas Southwestern Medical Center at Dallas (USA).

The press release about this study can be found in the Media Section here.

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