In 2015, the European Joint Programme – Neurodegenerative Disease Research (JPND) launched a joint transnational co-funded call in partnership with the European Commission in JPND priority areas. Among the 21 projects recommended for funding, a project with the participation of Cláudia Almeida from the Neuronal Trafficking in Aging Lab, entitled NAB3: Development of a Novel Multicellular In Vitro Model of Alzheimer’s disease-like Blood-Brain Barrier was one of the selected, based on scientific excellence and budget availability.
Scope of NAB3 Project:
"A striking challenge in diagnosis and therapy of neurodegenerative diseases is the design of drugs capable of crossing the blood-brain barrier (BBB), a tightly regulated barrier that prevents the passage of drugs from the blood to the brain. In vitro cellular BBB models are available, but they mimic only healthy conditions without taking into account the BBB alterations associated with neurodegenerative diseases, like Alzheimer’s disease (AD).
This project aims to develop and characterize a complex in vitro model of the BBB in AD conditions, built up with different cellular types combined with organotypic brain slices or neuronal cultures.
This newly designed in vitro model will be realized thanks to the expertise and the multidisciplinarity of the consortium in genetic engineering, physiology, neurobiology, neuroanatomy and biochemistry. The expected results will provide an innovative tool to i) obtain new information on the pathogenesis and pathophysiology of AD; ii) conduct more advanced early drug development and pre-clinical studies; and iii) devise new diagnostic or therapeutic strategies."
Coordiantor: Francesca Re, University of Milano-Bicocca, Italy
Partners: Claudia Almeida, Universidade NOVA de Lisboa, Portugal; Thomas G. Ohm, Charite Universitätsmedizin Berlin, Germany; Wiep Scheper, VU University Medical Center, Netherlands; Sandrine Bourdoulous, Inserm, Institut Cochin, Paris, France
To learn more about these projects selected visit the JPco-fuND Projects website.
The EU Joint Programme – Neurodegenerative Disease Research (JPND) is the largest global research initiative aimed at tackling the challenge of neurodegenerative diseases.
The ultimate goal of JPND is to find cures for neurodegenerative diseases and to enable early diagnosis for early targeted treatments. However, it is not possible to give definitive predictions on how long this might take to happen.