Proliferation and Fate Regulation of Stem Cells

Homem Catarina-0013

Catarina Homem

Principal Investigator
PhD in Biology, University of North Carolina-Chapel Hill/ University NOVA of Lisbon
PhD candidate; 3rd Gulbenkian PhD Programme in Biomedicine (PGDB3)
Graduation in Biochemistry, Porto University

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Location:

CEDOC
Campus Sant'Ana
Pólo de Investigação, NMS, UNL
Rua do Instituto Bacteriológico, nº 5
1150-082 Lisboa, Portugal

Phone: (+351) 218 803 101
E-mail: catarina.homem(at)nms.unl.pt

 
 

 
 
 

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Main interests

In every animal embryo, stem cells are required for the development, growth and regeneration of tissues and organs. At some point, the stem cells have done their job and must disappear. In fact, in adult animals only a few stem cells are still present.
However if unnecessary stem cells are left behind, malignant tumors can develop from them, in contrast if they disappear prematurely developmental defects can occur.

One and half orangesOur group uses the fruit fly Drosophila melanogaster as a model to study the mechanisms that regulate stem cell proliferation and fate during development. We are mainly focused in how temporal cues regulate the proliferation and fate of neural stem cells and their daughter cells. We are also studying how metabolism and nutrition affect stem cells and consequently animal development.

The understanding of how stem cells are temporally regulated and how they are influenced by external signals is crucial for the understanding of many developmental diseases, tumors and for their use in regenerative medicine.

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FIND OUT MORE about the Proliferation and Fate Regulatuon of Stem Cells Lab Research in the following news:

- Cientista portuguesa descobre papel de um gene na regulação celular com implicações no cancro
- A diaphanous control during embryo formation
- Cientista portuguesa descobre relação entre um gene específico e o cancro
- Wie sich Stammzellen zu Tode hungern
- Wiener Forscher entdeckten, wie sich Stammzellen selbst beseitigen
- Stem cells go on a diet
- How brain tumors develop from stem cells

 
 
 

Projects

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EMBO Installation Grant - Temporal and metabolic regulation of stem cells

 
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HHMI-Wellcome International Research Scholar

Selected Publications
  • Homem CC, Repic M, Knoblich JA. (2015) Proliferation control in neural stem and progenitor cells. Nat Rev Neurosci. Epub ahead of print. doi: 10.1038/nrn4021.
  • Homem CC, Steinmann V, Burkard TR, Jais A, Esterbauer H, Knoblich JA. (2014) Ecdysone and mediator change energy metabolism to terminate proliferation in Drosophila neural stem cells.
    Cell; 158(4):874-88. doi: 10.1016/j.cell.2014.06.024
  • Eroglu E, Burkard TR, Jiang Y, Saini N, Homem CC, Reichert H, Knoblich JA. (2014) SWI/SNF complex prevents lineage reversion and induces temporal patterning in neural stem cells.
    Cell; 156(6):1259-73. doi: 10.1016/j.cell.2014.01.053.
  • Homem CC, Reichardt I, Berger C, Lendl T, Knoblich JA. (2013) Long-term live cell imaging and automated 4D analysis of drosophila neuroblast lineages.
    PLoS One; 8(11):e79588. doi: 10.1371/journal.pone.0079588. eCollection 2013.
  • Homem CC, Knoblich JA. (2012) Drosophila neuroblasts: a model for stem cell biology. Development; 139(23):4297-310. doi: 10.1242/dev.080515
  • Homem CC, Peifer M. (2009) Exploring the roles of diaphanous and enabled activity in shaping the balance between filopodia and lamellipodia. Mol Biol Cell; 20(24):5138-55. doi: 10.1091/mbc.E09-02-0144.
  • Gates J, Nowotarski SH, Yin H, Mahaffey JP, Bridges T, Herrera C, Homem CC, Janody F, Montell DJ, Peifer M. (2009) Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis. Dev Biol; 333(1):90-107. doi: 10.1016/j.ydbio.2009.06.030.
  • Homem CC, Peifer M. (2008) Diaphanous regulates myosin and adherens junctions to control cell contractility and protrusive behavior during morphogenesis. Development; 135(6):1005-18. doi: 10.1242/dev.016337.
  • Stevens TL, Rogers EM, Koontz LM, Fox DT, Homem CC, Nowotarski SH, Artabazon NB, Peifer M. (2008) Using Bcr-Abl to examine mechanisms by which abl kinase regulates morphogenesis in Drosophila. Mol Biol Cell; 19(1):378-93. PMID: 17959833 Free PMC Article
  • Fox DT, Homem CC, Myster SH, Wang F, Bain EE, Peifer M. (2005) Rho1 regulates Drosophila adherens junctions independently of p120ctn. Development; 132(21):4819-31. PMID: 16207756 Free Article

Postdoctoral research position

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Applications are invited for a postdoctoral research position to study “The metabolic regulation of stem cells during development” in the Proliferation and Fate Regulation of Stem Cells group led by Catarina Homem.

In every animal embryo, stem cells are required for the development, growth and regeneration of tissues and organs. At some point, the stem cells have done their job and must disappear. C. Homem Lab uses the fruit fly Drosophila melanogaster as a model to study the mechanisms that regulate stem cell proliferation and fate during development. In particular, the Lab is studying how metabolism and nutrition affect stem cells and consequently animal development.

Applicants should hold a PhD degree in a relevant subject area. Experience with cell imaging and Drosophila would be advantageous but not essential. The position is initially funded for one year, with possibilities of extension. Candidates are also expected to apply for competitive national and international funding sources.

To apply, send one single PDF file including CV, cover letter and the name of 3 referees, to catarina.homem@nms.unl.pt.
Applications start on August 1 and will continue until the position is filled.

Team photos

Grupo Prof. Catarina Homem 2017-04-04 -

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