Neuronal Control of Metabolic Disturbances: Therapeutic Strategies

silvia conde

Silvia Conde

Principal Investigator

CV

Location:

CEDOC
Campus Sant'Ana
Pólo de Investigação, NMS, UNL
Rua Câmara Pestana, nº 6, Lab 3.16
1150-082 Lisboa, Portugal

Phone: (+351) 218 803 101 (ext. 26022)

Lab Phone: (+351) 218 803 100 (ext. 26012/3)

E-mail: silvia.conde(at)nms.unl.pt

Main interests

Over 8.3% of the global population suffers from type 2 diabetes, a disease that is expected to affect over 552 million people by 2030. Our group is focused on the pathophysiology of metabolic diseases and the identification of prevention strategies and treatment interventions that would help stem this epidemic.

Our primary focus is the carotid body, a peripheral chemoreceptor whose main stimulus is hypoxia. We have recently discovered that the carotid body also senses hyperinsulinemia, and have shown that carotid body overactivation is present in hypercaloric animal models of insulin resistance and hypertension. We have also found that carotid sinus nerve resection prevents the development of insulin resistance, hypertension and obesity induced by hypercaloric diets, suggesting that the carotid body is involved in the genesis of metabolic disturbances. We are now mapping carotid body neural pathways and disclosing the molecular mechanisms involved in the aetiology of insulin resistance and obesity.

Additionally, we have a second line of reasearch that intends to explore the benefitial/deleterious effects of chronic vs acute caffeine intake on insulin sensitivity and the mechanism underlying these effects. The mapping of neural pathways and the disclosure of the molecular mechanims involved in type 2 diabetes and related co-morbidities should reveal new targets for therapeutical intervention.

 
 
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- Medalhas de Honra L'Oréal Portugal para as Mulheres na Ciência

Projects

Aug 2016 - Feb 2018 - “The Carotid Body as a therapeutic target in metabolic diseases: Mapping carotid sinus nerve activity in diabetes rat models: Lisbon Stage 2”. supported by: Galvani Biolectronics - 340.316,00€ - PI: Sílvia Conde

Nov 2013 - Apr 2016 - “The Carotid Body as a therapeutic target in metabolic diseases: Mapping carotid sinus nerve activity in diabetes rat models”. supported by: GSK Biolectronic Exploratory Funding - 147.905,56€ PI: Sílvia Conde

Mar 2015 - Apr 2016 - "Wireless Interfacing of the Carotid Sinus Nerve for Hypoxic Response Modulation". Colaboration project between CEDOC, NOVA Medical School, Universty of Texas and Illinois Institute of Technology. Supported by: GSK Innovation Challenge Funding. 200.000$ (total), 49.728$ (Silvia Conde). co-PIs: Mário Romero and Sílvia Conde

Mar 2014 - Feb 2015 – “Mapping the sympathetic efferent activity in carotid-body mediated insulin resistance”. Supported by: Portuguese Foundation for Science and Technology (EXPL/NEU-SCC/2183/2013) – 48.371€ PI: Maria Guarino

Nov 2013 - Nov 2014 - "Mapping carotid sinus nerve activity in diabetes rat models" Supported by: GSK Bioelectronic Exploratory Funding Ref: D00006317 - 96.105$ PI: Silvia Conde

Mar 2011 - Dec 2013 - "Insulin and carotid body: a new mechanism for insulin resistance and hypertension.".Supported by Portuguese Foundation for Science and Tecnhology Project Reference: PTDC/SAU-ORG/11149/2009 - 100.000€ PI: Silvia Conde

Nov 2009 - May 2012: Effect of chronic caffeine intake on insulin resistance and hypertension: mechanistic and therapeutic approach. Supported by: Sociedade Portuguesa Diabetologia/Lilly Portugal - 10.000 € PI: Silvia Conde and Maria Guarino

Prizes and Awards

2016 National Diabetes Award 2016 from the Portuguese Society of Diabetes

2016 Hargreaves 2016 Award from the Portuguese Society of Diabetes/JABA RECORDATI

2014 Best project in the Translational Research category by Fundação AstraZeneca Innovate Competition. (to Bernardete Melo)

2014 1st Prize “De Castro-Heymans- Neil Award” by ISAC (International Society for Arterial Chemoreception) to the best work presented by a Young Research each triennial ISAC Meeting. ( to Maria João Ribeiro)

2014 EPHAR Young Investigator Award from the Federation of European Pharmacological Societies to best scientific article published in the area of pharmacology. (to Maria João Ribeiro)

2012 Hargreaves 2012 Award from the Portuguese Society of Diabetes /JABA RECORDATI

2009 L’Oreal Portugal Medals of Honour for Women in Science from L’Oreal, Portuguese Science and Technology Foundation and UNESCO

2009 Nuno Castel Branco Award from the Portuguese Society of Diabetes and Lilly Portugal

2002 1st Prize “De Castro - Heymans – Neil Award” from the International Society for Arterial Chemoreception

2002 Pfizer Honour Young Researcher Prize from the Portuguese Society of Medical Sciences

1999 Training Fellowship - nº1/3.2/PRODEPIII/2000 from Fundo Social Europeu e Estado Português

Patents
  • Conde SV, Chew DJ, Famm K, Guarino MP, Holinski B, Patel S (2015) Neuromodulation device. Patent PCT/PT2015/000047.
Publications
  • Gonzalez C, Conde SV, Gallego-Martin T, Olea E, Gonzalez-Obeso E, Ramirez M, Yubero S, Agapito MT, Gomez-Niño A, Obeso A, Rigual R, Rocher A (2014) Fernando De Castro and the discovery of the arterial chemoreceptors. Front. Neuroanat. 8:25 doi: 10.3389/fnana.2014.00025
  • Conde SV and Peers C (2013) Carotid body chemotransduction gets the human touch. J Physiol 591:6131-2.
  • Ribeiro MJ, Sacramento JF, Gonzalez C, Guarino MP, Monteiro EC, Conde SV (2013) Carotid body denervation prevents the development of insulin resistance and hypertension induced by hypercaloric diets. Diabetes 62:2905-16
  • Guarino MP, Ribeiro MJ, Sacramento JF, Conde SV (2013) Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity. Age 35:1755-65
  • Sacramento JF, Ribeiro MJ, Guarino MP, Conde SV (2013) Are the acute caffeine effects on insulin sensitivity mediated by adenosine receptors? Proceedings of the 6th European Congress of Pharmacology, 223-228
  • Conde SV, Ribeiro MJ, Obeso A, Rigual R, Monteiro EC, Gonzalez C (2012) Chronic caffeine intake in adult rat inhibits carotid body sensitization produced by chronic sustained hypoxia but maintains intact chemoreflex output. Mol Pharmacol 2012 82:1056-65.
  • Conde SV, Obeso A, Monteiro EC, Gonzalez C (2012) Effect of chronic caffeine intake on carotid body catecholamine dynamics in control and chronically hypoxic rats. Adv Exp Med Biol 758:315-23
  • Conde SV, Monteiro EC, Rigual R, Obeso A, Gonzalez C (2012) Hypoxic intensity: a determinant for the contribution of ATP and adenosine to the genesis of carotid body chemosensory activity. J Appl Physiol. 112:2002-10.
  • Conde SV, Nunes da Silva T, Gonzalez C, Mota Carmo M, Monteiro EC, Guarino MP. (2012) Chronic caffeine intake decreases circulating catecholamines and prevents diet-induced insulin resistance and hypertension in rats. Br J Nutr 107:86-95
  • Gonzalez-Martín M.C., Vega-Agapito M.V, Conde S.V., Castañeda J. Bustamante R., Olea E., Perez-Vizcaino F., Gonzalez C. and Obeso A. (2011) Carotid body function and ventilatory responses in intermittent hypoxia. Evidence for anomalous brainstem integration of arterial chemoreceptor input. J Cell Physiol. 226:1961-9
  • Gonzalez C., Agapito M.T., Rocher A., Gomez-Niño A., Rigual R., Castañeda J., Conde S.V. and Obeso A. (2010) A revisit to O(2) sensing and transduction in the carotid body chemoreceptors in the context of reactive oxygen species biology. Respir Physiol Neurobiol. Dec 174:317-30
  • Conde S.V., Monteiro E.C., Obeso A. and Gonzalez C. (2009) Adenosine in peripheral chemoreception: new insights into a historically overlooked molecule. In: Arterial Chemoreceptors. (Gonzalez et al., eds), pp 159-174. Springer, Netherlands
  • Conde S.V., Obeso A., Monteiro E.C. and Gonzalez C. (2009) The A2B-D2 receptor interaction that controls carotid body catecholamines release locates between the last two steps of hypoxic transduction cascade. In: Arterial Chemoreceptors. (Gonzalez et al., eds), pp 175-182. Springer, Netherlands
  • Conde S.V., Gonzalez C., Batuca J.R., Monteiro E.C. and Obeso A. (2008) An antagonistic interaction between A2B adenosine and D2 dopamine receptors modulates the function of rat carotid body chemoreceptor cells. J Neurochem. 107, 1369-1381.
  • Conde S.V., Obeso A. and Gonzalez C. (2007) Low glucose effects on rat carotid body chemoreceptor cells secretory responses and action potential frequency in the carotid sinus nerve. J. Physiol. 585, 721-730.
  • Conde SV, Obeso A, Rigual R, Monteiro EC and Gonzalez C (2006) Function of the rat carotid body chemoreceptors in aging. J Neurochem. 99, 711-723.
  • Conde S.V., Obeso A., Vicario I., Rigual R., Rocher A. and Gonzalez C. (2006), Caffeine inhibition of rat carotid body chemoreceptors is mediated by A2A and A2B adenosine receptors, J. Neurochem., 98, 616-628.
  • Conde SV and Monteiro EC (2006) Activation of nicotinic ACh receptors with alpha 4 subunits induces adenosine release at the rat carotid body. Br J Pharmacol., 147, 783-789.
  • Conde SV, Caceres AI, Vicario I, Rocher A, Obeso A and Gonzalez C.(2006) An overview on the homeostasis of Ca2+ in chemoreceptor cells of rabbit and rat carotid bodies. Adv. Exp. Med. Biol. 580, 215-222
  • Conde SV and Monteiro EC (2006) Profiles for ATP and adenosine release at the carotid body in response to O2 concentrations. Adv. Exp. Med. Biol. 580, 179-184
  • Conde SV and Monteiro EC (2004) Hypoxia induces adenosine release from the rat carotid body. J Neurochem, 89:1148-56.
  • Conde SV and Monteiro EC (2003) Adenosine-acetylcholine interactions at the rat carotid body. Adv Exp Med Biol. 536:305-11.

Collaborations

- Rui Pinto - Instituto de Telecomunicações and Politécnico de Leiria

- Paulo Matafome and Raquel Seiça - IBILI Coimbra

- Pedro Lima - CEDOC, NOVA Medical School

- Miguel Mota Carmo - Hospital Santa Marta, CHLC and CEDOC, FCM

- Paulo Vera-Cruz - CEDOC, FCM, and Franscisco Guerreiro -Centro de Medicina Subaquática e Hiperbárica

- Mário Romero - University of Texas, Dallas (UTD), USA

- Phillipe Blancou and Nicolas Glaichenhaus - INSERM, Université Nice, Nice, France

- Ana Obeso - Faculty of Medicine, University of Valladolid, Spain

Team photos

foto grupo S Conde