Neurology: Stroke and Dementia

Viana Batista 24-6-2013 - 7751

Miguel Viana Baptista

Principal Investigator



Campus Hospital Egas Moniz
Serviço de Neurologia
Rua da Junqueira, 126
1349-019 Lisboa

Phone: (+351) 213 629 353
Fax: (+351) 213 622 091
E-mail: mvianabaptista(at)

Main interests

Our lab main scientific interests include on one hand those related to cerebrovascular disease (dementia, vascular dementia, age related white matter changes, stroke in young adults and uncommon causes of stroke), and on the other hand those related to Parkinson's disease (cognitive / psychiatric changes and REM sleep behaviour disorder).

The two main projects on cerebrovascular disease are the PORTYSTROKE (main objective is to screen genetic conditions in Young Stroke patients) and a cooperative project with Instituto Superior Técnico on MRI: Noninvasive quantitative imaging of cerebral physiology: application to normal aging and small vessel diseases. PTDC/BBB-IMG/2137/2012.

We have also an on-going project on Parkinson's disease including cognitive changes, RBD, and impulse control.

Research Areas

Stroke; Age-relate White Matter changes; Stroke in Young Adults; CADASIL; Fabry Disease; General Neurology; Parkinson's disease

Discover more about the Neurology: Stroke and Dementia Lab

AVC – Demora a ligar 112 atrasa tratamento


PORTYSTROKE" Screening genetic conditions in Young Stroke patients, funded by Genzyme, Portugal. 2006-2012.

  • Marto JP, Dias M, Alves JN, Montes V, Beato-Coelho J, Marques-Matos C, de Sousa A, Bernardo F, Calado S, Viana-Baptista M (2017) Stroke in adults with Down syndrome. J Neurol Sci. 2017 Apr 15;375:279-280. doi: 10.1016/j.jns.2017.02.014. Epub 2017 Feb 8.
  • Bugalho P, Alves L, Miguel R. Gait dysfunction in Parkinson's disease and normal pressure hydrocephalus: a comparative study. J Neural Transm. 2013 Aug;120(8):1201-7. doi: 10.1007/s00702-013-0975-3.
  • Matias G, Calado S, Viana-Baptista M; in cooperation with the Portuguese Stroke Society. Stroke prevention: behaviors and attitudes of the healthcare professionals. Int J Stroke. 2013 Jul;8(5):E21. doi: 10.1111/ijs.12002.
  • Morais RB, Sousa I, Leiria MJ, Marques C, Ferreira JC, Cabral P. Pseudotumoral acute hemicerebellitis in a child. Eur J Paediatr Neurol. 2013 Mar;17(2):204-7. doi: 10.1016/j.ejpn.2012.06.005.
  • Bugalho P, Oliveira-Maia AJ. Impulse control disorders in Parkinson's disease: Crossroads between neurology, psychiatry and neuroscience. Behav Neurol. 2012 Dec 14. [Epub ahead of print]
  • Viana-Baptista M. Stroke and Fabry disease. J Neurol. 2012 Jun;259(6):1019-28. doi: 10.1007/s00415-011-6278-4.
  • Alves L, Correia AS, Miguel R, Alegria P, Bugalho P. Alzheimer's disease: a clinical practice-oriented review. Front Neurol. 2012;3:63. doi: 10.3389/fneur.2012.00063.
  • Bugalho P, da Silva JA, Cargaleiro I, Serra M, Neto B. Psychiatric symptoms screening in the early stages of Parkinson's disease. J Neurol. 2012 Jan;259(1):124-31. doi: 10.1007/s00415-011-6140-8.
  • Cargaleiro I, Serra M, Alves da Silva J, Neto B, Gonçalves-Pereira M, Bugalho P. Psychosis assessment in early-stage Parkinson's disease: comparing Parkinson's psychosis questionnaire with the brief psychiatric rating scale in a Portuguese sample. Parkinsons Dis. 2012;2012:469126. doi: 10.1155/2012/469126.
  • Ferreira J, Ferreira D, Viana-Baptista M, Bettencourt P, Cernadas R, Crespo F. Dabigatran for stroke prevention in nonvalvular atrial fibrillation: answers to challenging "real-world" questions. Thrombosis. 2012;2012:867121. doi: 10.1155/2012/867121.
  • Bugalho P, Vale J. Brief cognitive assessment in the early stages of Parkinson disease. Cogn Behav Neurol. 2011 Dec;24(4):169-73. doi: 10.1097/WNN.0b013e3182350a1f.
  • Paiva T, Bugalho P, Bentes C. Dreaming and cognition in patients with frontotemporal dysfunction. Conscious Cogn. 2011 Dec;20(4):1027-35. doi: 10.1016/j.concog.2011.06.008.
  • Bugalho P, Paiva T. Dream features in the early stages of Parkinson's disease. J Neural Transm. 2011 Nov;118(11):1613-9. doi: 10.1007/s00702-011-0679-5.
  • Barahona-Corrêa B, Bugalho P, Guimarães J, Xavier M. Obsessive-compulsive symptoms in primary focal dystonia: a controlled study. Mov Disord. 2011. Oct;26(12):2274-8. doi: 10.1002/mds.23906.
  • Ferro JM, Crassard I, Coutinho JM, Canhão P, Barinagarrementeria F, Cucchiara B, Derex L, Lichy C, Masjuan J, Massaro A, Matamala G, Poli S, Saadatnia M, Stolz E, Viana-Baptista M, Stam J, Bousser MG; Second International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT 2) Investigators. Decompressive surgery in cerebrovenous thrombosis: a multicenter registry and a systematic review of individual patient data. Stroke. 2011 Oct;42(10):2825-31. doi: 10.1161/STROKEAHA.111.615393.
  • Viana-Baptista M, Bugalho P, Jordão C, Ribeiro O, Esperança-Pina JA, Ferro J. Motor dysfunction correlates with frontal white matter ischemic changes in patients with leukoaraiosis. J Aging Res. 2011;2011:950341. doi: 10.4061/2011/950341.
  • Bugalho P, da Silva JA, Neto B. Clinical features associated with REM sleep behavior disorder symptoms in the early stages of Parkinson's disease. J Neurol. 2011 Jan;258(1):50-5. doi: 10.1007/s00415-010-5679-0.
  • Lampreia T, Bugalho P, Soares P, Santos L. Delayed-onset parkinsonian tremor following a mesencephalic lesion. Parkinsonism Relat Disord. 2011 Jan;17(1):65-6. doi: 10.1016/j.parkreldis.2010.08.024.
  • Canas N, Breia P, Soares P, Saraiva P, Calado S, Jordão C, Vale J. The electroclinical-imagiological spectrum and long-term outcome of transient periictal MRI abnormalities. Epilepsy Res. 2010 Oct;91(2-3):240-52. doi: 10.1016/j.eplepsyres.2010.07.019.
  • Canas N, Soares P, Calado S, Pestana R, Ribeiro C, Vale J. Pathophysiology and long-term outcome of reversible tumor-like lesions induced by presenting status epilepticus. J Neuroimaging. 2010 Apr;20(2):169-74. doi: 10.1111/j.1552-6569.2008.00334.x.
  • Krug T, Manso H, Gouveia L, Sobral J, Xavier JM, Albergaria I, Gaspar G, Correia M, Viana-Baptista M, Simões RM, Pinto AN, Taipa R, Ferreira C, Fontes JR, Silva MR, Gabriel JP, Matos I, Lopes G, Ferro JM, Vicente AM, Oliveira SA. Kalirin: a novel genetic risk factor for ischemic stroke. Hum Genet. 2010 Mar;127(5):513-23. doi: 10.1007/s00439-010-0790-y.
  • Baptista MV, Ferreira S, Pinho-E-Melo T, Carvalho M, Cruz VT, Carmona C, Silva FA, Tuna A, Rodrigues M, Ferreira C, Pinto AA, Leitão A, Gabriel JP, Calado S, Oliveira JP, Ferro JM; PORTuguese Young STROKE Investigators. Mutations of the GLA gene in young patients with stroke: the PORTYSTROKE study--screening genetic conditions in Portuguese young stroke patients. Stroke. 2010 Mar;41(3):431-6. doi: 10.1161/STROKEAHA.109.570499.
  • Vale J, Bugalho P, Silveira I, Sequeiros J, Guimarães J, Coutinho P. Autosomal dominant cerebellar ataxia: frequency analysis and clinical characterization of 45 families from Portugal. Eur J Neurol. 2010 Jan;17(1):124-8. doi: 10.1111/j.1468-1331.2009.02757.x.
  • Rosa A, Fonseca BV, Krug T, Manso H, Gouveia L, Albergaria I, Gaspar G, Correia M, Viana-Baptista M, Simões RM, Pinto AN, Taipa R, Ferreira C, Fontes JR, Silva MR, Gabriel JP, Matos I, Lopes G, Ferro JM, Vicente AM, Oliveira SA. Mitochondrial haplogroup H1 is protective for ischemic stroke in Portuguese patients. BMC Med Genet. 2008 Jul 1;9:57. doi: 10.1186/1471-2350-9-57.
  • Viana-Baptista M, Bugalho P, Jordão C, Ferreira N, Ferreira A, Forjaz Secca M, Esperança-Pina JA, Ferro JM. Cognitive function correlates with frontal white matter apparent diffusion coefficients in patients with leukoaraiosis. J Neurol. 2008 Mar;255(3):360-6. doi: 10.1007/s00415-008-0661-9.
  • Guimarães J, Bugalho P, Coutinho P. Pathological crying in patients with Machado-Joseph disease. Mov Disord. 2008 Feb 15;23(3):470-1.
  • Bugalho P, Corrêa B, Guimarães J, Xavier M. Set-shifting and behavioral dysfunction in primary focal dystonia. Mov Disord. 2008 Jan 30;23(2):200-6.
  • Bugalho P, Alves L. Normal-pressure hydrocephalus: white matter lesions correlate negatively with gait improvement after lumbar puncture. Clin Neurol Neurosurg. 2007 Nov;109(9):774-8.
  • Bugalho P, Guimarães J. Gait disturbance in normal pressure hydrocephalus: a clinical study. Parkinsonism Relat Disord. 2007 Oct;13(7):434-7.
  • Bugalho P, Viana-Baptista M, Jordão C, Secca MF, Ferro JM. Age-related white matter lesions are associated with reduction of the apparent diffusion coefficient in the cerebellum. Eur J Neurol. 2007 Sep;14(9):1063-6.
  • Temudo T, Oliveira P, Santos M, Dias K, Vieira J, Moreira A, Calado E, Carrilho I, Oliveira G, Levy A, Barbot C, Fonseca M, Cabral A, Dias A, Cabral P, Monteiro J, Borges L, Gomes R, Barbosa C, Mira G, Eusébio F, Santos M, Sequeiros J, Maciel P. Stereotypies in Rett syndrome: analysis of 83 patients with and without detected MECP2 mutations. Neurology. 2007 Apr 10;68(15):1183-7.
  • Guimarães J, Santos L, Bugalho P. Painful legs and moving toes syndrome associated with Hashimoto's disease. Eur J Neurol. 2007 Mar;14(3):343-5.
  • ESPRIT Study Group, Halkes PH, van Gijn J, Kappelle LJ, Koudstaal PJ, Algra A. Medium intensity oral anticoagulants versus aspirin after cerebral ischaemia of arterial origin (ESPRIT): a randomised controlled trial. Lancet Neurol. 2007 Feb;6(2):115-24.
  • Bessa C, Teixeira CA, Mangas M, Dias A, Sá Miranda MC, Guimarães A, Ferreira JC, Canas N, Cabral P, Ribeiro MG. Two novel CLN5 mutations in a Portuguese patient with vLINCL: insights into molecular mechanisms of CLN5 deficiency. Mol Genet Metab. 2006 Nov;89(3):245-53.
  • Bugalho P, Correa B, Guimarães J, Xavier M. Obsessive-compulsive disorder and executive deficits in two patients with primary dystonia. Parkinsonism Relat Disord. 2006 Sep;12(6):388-91.
  • Bugalho P, Correa B, Viana-Baptista M. [Role of the cerebellum in cognitive and behavioural control: scientific basis and investigation models]. Acta Med Port. 2006 May-Jun;19(3):257-67. Epub 2006 Sep 7. Review. Portuguese.
  • Calado S, Viana-Baptista M. Benign cerebral angiopathy; postpartum cerebral angiopathy: characteristics and treatment. Curr Treat Options Cardiovasc Med. 2006 May;8(3):201-12.
  • Cabral P. Attention deficit disorders: are we barking up the wrong tree? Eur J Paediatr Neurol. 2006 Mar;10(2):66-77. Epub 2006 Apr 17. Review. PubMed PMID: 16617029.


Hospital Egas Moniz CHLO, Portugal.

Team photos

NEUROLOGIA  E. MONIZ 24-6-2013 - 7766

NEUROLOGIA  E MONIZ 24-6-2013 - 7753