Integrated Pathophysiological Mechanisms

Nuno Neupart  28-6-2013 -7852

Nuno Neuparth

Principal Investigator

CV

Location:

CEDOC
Campus Sant'Ana
Pólo de Investigação, NMS, UNL
Rua do Instituto Bacteriológico, nº 5
1150-082 Lisboa, Portugal

Phone: (+351) 218 803 023
Fax: (+351) 218 851 920
E-mail: nuno.neuparth(at)nms.unl.pt

Main interests:

This group started focused in respiratory diseases until 2013. The main objectives were the impact of air quality on the health of the population in several contexts:
1.In schools attended by children
2.In children day care centres
3.In geriatric nursing homes
4.In industrial complexes
Form 2014 on, the focus of our group moved to the integrated mechanisms of disease in a multidisciplinary context:
1. Air quality and respiratory diseases
2. Aging and integrated mechanisms of disease
3. Mechanisms of imunoallergic disease
4. Mechanisms of interstitial lung disease
5. Genetics and respiratory diseases
6. Mechanisms of infection (acute and chronic)
7. Mechanisms of viral infection
8. Biomarkers of disease
9. Integrated mechanisms of cardiovascular disease
10. Cough mechanisms

Research Areas:

Air quality and respiratory diseases - Pedro Martins
Air pollution is a ubiquitous and complex exposure associated with both short term and long term health effects. In developed countries, the major air pollutants include particulate matter (PM), nitrogen oxides (NOx), ozone, volatile organic compounds (VOCs) and sulphur dioxide (SO2). Exposure to these chemical contaminants is associated either with respiratory and cardiovascular diseases, and a lower life expectancy.
Outdoor and indoor environments should be considered when studying the effects on human health. Even though, in the last years particular attention was given to indoor air quality as more than 80% of our time is spent indoors.
The pathophysiologic mechanisms underlying the aggression of air pollutants are not properly understood. It is thought that after inhalation, air pollutants could induce oxidative stress, which would be responsible for airways inflammation. The progression of oxidative stress and airways inflammation, seems to contribute for the local and systemic effects of the air pollutants.
In the last years our group has participated in different studies (SAUDAR, ENVIRH, INSPIRAR, GERIA) about the effects of air pollution exposure over the airways, improving the knowledge on this area.

Aging and integrated mechanisms of disease - Maria Amália Botelho
Human ageing and longevity extension grew markedly since the last quarter of the XXth century. A comprehensive approach to its significance in people life and care professionals work plans is being made since then. Notwithstanding, there is still a great need to understand pathways of ageing and chronic disease and how to delay the elders vulnerability.
A compact comprehensive geriatric biopsychossocial evaluation that was developed as a post doc work of a member of our team is already in use at the national Portuguese long term care service.
The main objective of the group is to go further, and implement an efficient model of systematic comprehensive evaluation and referral approach of people aged more than 64 years. We intend to validate the revised comprehensive geriatric biopsychossocial evaluation method and to standardize a Portuguese observational approach on frailty, as an entity that characterizes extreme biological ageing and needs to be better understood, in order to fulfill the hope of delaying the vulnerability that comes with advancing age.

Centro Pneumológico de Coimbra - Carlos Robalo Cordeiro
Centro Pneumológico de Coimbra is based in the Department of Pneumonology and alergology of Coimbra University Hospital and it includes a multidisciplinary research unit, functioning in collaboration with several Departments and Laboratories of Coimbra University Hospital and Medical School. The scientific projects are mostly based on the inpatient population and the outpatient clinic. However, there is also a close connection with the community and the involvement of animal or virtual models, which are developed within a multidisciplinary scope that includes imaging, lung function, morphology and genetic studies. The assignments undertaken by the CP focus not only on deep lung behaviour when exposed to various aggressions (environmental, occupational or infectious) but also other areas such as pulmonary oncogenesis, respiratory allergology and interstitial lung diseases. Of the several projects being developed there are, actually, 3 main areas of interest: 1 - Studies on Lung Cancer, namely related with genes and mutations for metabolizing enzymes and with drug resistance markers through immunohistochemistry; 2 - The Immunology and Clinical Immunoallergology studies, namely related a) with the Asthma European Network, intending to spread excellence in the management of asthmatic patients, at this moment focused on the elderly population, b) with the dynamic evaluation of allergic inflammation and c) with several allergic responses; 3 - Studies in Interstitial Lung Diseases, specifically the genetic expression of mediators of fibrotic evolution and algorithms of clinical decisions based on clinics, radiology and laboratory data.

Mechanisms of infection (acute and chronic) - Pedro Póvoa
Patients under invasive mechanical ventilation are at increased risk of colonization, ventilator associated tracheobronchitis (VAT) and pneumonia (VAP); it is not clear the progression or the relation between these different conditions.
Our main objective is to correctly define these different clinical entities (diagnostic criteria, clinical impact and outcomes), to study different biomarkers and other non invasive approaches to help in the distinction between them, to perform a RCT to study if an adequate antibiotic therapy of patients with TAV prevent the progression to VAP and improve outcome

Mechanisms of viral infection - Paulo Paixão
The concept of a human virobiota (the viral component of the human microbiota), in the respiratory tract is recent, with some studies detecting viral presence in the upper respiratory tract in apparently healthy individuals. Most studies of microbiota have focused on their bacterial component and have expanded massively in these last few years, mostly focused in pediatric populations. Therefore, information concerning adult populations’ and particularly the elderly is scarce.
The main objective of our group is the study of the respiratory viruses and bacteria in different populations, particularly the elderly, and the clinical and biological consequences of their presence in the upper respiratory tract. Correlating the degree of systemic and local inflammation with viral presence in both symptomatic and asymptomatic patients will be an additional objective of our work.

Biomarkers of disease - Nuno Neuparth
This is an area with a potential for translational research and to the discovery of new biophysical biomarkers of disease. The group has been involved in the application of several biomarkers of disease, namely in the context of the effects of air pollution in the health of the population. Mediators of the asthmatic inflammation as exhaled nitric oxide and several diluted substances in the exhaled breath condensate, have been used by our group. The nasal airway is being studied by the development of a differential manometry equipment and articulation with the ciliary diseases group to look for clinically relevant biomarkers in nasal polyposis. In the context of acute infection our group is involved in the assessment of course of several serum biomarkers, namely CRP and PCT, in the diagnosis of VAP as well as in the assessment of its response to antibiotic therapy. Another area is the study of biomarkers as a tool for antibiotic stewardship.

Integrated mechanisms of cardiovascular disease - Pedro Araújo Gonçalves
The research on mechanisms of cardiovascular diseases have been focused in tree major fields. One is coronary artery disease, namely the identification of the vulnerable patient and the contribution of cardiac computed tomography for this evaluation. The second is hypertension, with a focus on the contribution of chronic hyperactivation of the sympathetic nervous system and the impact of an interventional procedure – renal denervation – in both blood pressure control and in surrogate markers of target organ damage. The third is interventional cardiology both for coronary artery disease as well as structural heart disease.
A possible fourth field of research that we would like to pursue is related to the cardiovascular adaptation to exercise.

Cough mechanisms - Nuno Neuparth
This is a new area of this research group and will explore the mechanisms involved in the three main validated phenotypes of cough: 1) gastroesophageal reflux; 2) Asthma and 3) post-nasal drip phenotypes, profiting on the physical neighbourhood of Dr. Luís Novais Lab (CEDE - Centro de Estudos de Doenças Esofágicas).

Projects

OLDER - Obstructive Lung Diseases in Elders, funded by AstraZeneca
2015-2017
See the Website Here

FISIOPOL - Physiological Factors in the Etiology of Nasal Polyposis, funded by NOVA Saúde
2015-2016

GERIA - Geriatric Study in Portugal on Health Effects of Air Quality in Elderly Care Centers, funded by FCT
2012-2015
See the Website Here

ENVIRH - Environment and Health in Children Day Care Centres, funded by FCT
2010-2013
See the Website Here

INSPIRAR - Air Quality Exposure and Human Health in Industrialized Urban Areas, funded by FCT
2010-2013
See the Website Here

Publications

Publications in International Peer-Reviewed Journals

  • Bousquet J, Bewick M, Arnavielhe S, Mathieu-Dupas E, Murray R, Bedbrook A, Caimmi DP, VandenPlas O, Hellings PW, Bachert C, Anto JM, Bergmann KC, Bindslev-Jensen C, Bosnic-Anticevitch S, Bouchard J, Canonica GW, Chavannes NH, Cruz AA, Dahl R, Demoly P, De Vries G, Devillier P, Fink-Wagner A, Fokkens WJ, Fonseca J, Guldemond N, Haahtela T, Hellqvist-Dahl B, Just J, Keil T, Klimek L, Kowalski ML, Kuna P, Kvedariene V, Laune D, Larenas-Linnemann D, Mullol J, Pereira AM, Carreiro-Martins P, Melén E, Morais-Almeida M, Nogueira-Silva L, O'Hehir RE, Papadopoulos NG, Passalacqua G, Portejoie F, Price D, Ryan D, Samolinski B, Sheikh A, Simons FE, Spranger O, Bom AT, Tomazic PV, Triggiani M, Valero A, Valovirta E, Valiulis A, van Eerd M, Wickman M, Young I, Zuberbier T (2017) Work productivity in rhinitis using cell phones: The MASK pilot study. Allergy. 2017 Apr 7. doi: 10.1111/all.13177. [Epub ahead of print]
  • Schultz MJ, Dunser MW, Dondorp AM, Adhikari NK, Iyer S, Kwizera A, Lubell Y, Papali A, Pisani L, Riviello BD, Angus DC, Azevedo LC, Baker T, Diaz JV, Festic E, Haniffa R, Jawa R, Jacob ST, Kissoon N, Lodha R, Martin-Loeches I, Lundeg G, Misango D, Mer M, Mohanty S, Murthy S, Musa N, Nakibuuka J, Serpa Neto A, Nguyen Thi Hoang M, Nguyen Thien B, Pattnaik R, Phua J, Preller J, Povoa P, Ranjit S, Talmor D, Thevanayagam J, Thwaites CL, Global Intensive Care Working Group of the European Society of Intensive Care Medicine (2017) Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future. Intensive Care Med. 2017 Mar 27. doi: 10.1007/s00134-017-4750-z. [Epub ahead of print]
  • Bousquet J, Caimmi DP, Bedbrook A, Bewick M, Hellings PW, Devillier P, Arnavielhe S, Bachert C, Bergmann KC, Canonica GW, Chavannes N, Cruz AA, Dahl R, Demoly P, De Vries G, Mathieu-Dupas E, Fink Wagner A, Fonseca J, Guldemond N, Haahtela T, Hellqvist-Dahl B, Just J, Keil T, Klimek L, Kowalski ML, Kuitunen M, Kuna P, Kvedariene V, Laune D, Pereira AM, Carreiro-Martins P, Melén E, Morais-Almeida M, Mullol J, Muraro A, Murray R, Nogueira-Silva L, Papadopoulos NG, Passalacqua G, Portejoie F, Price D, Ryan D, Samolinski B, Sheikh A, Siroux V, Spranger O, Bom AT, Tomazic PV, Valero A, Valovirta E, Valiulis A, VandenPlas O, van der Meulen S, van Eerd M, Wickman M, Zuberbier T. (2017) Pilot study of mobile phone technology in allergic rhinitis in European countries. The MASK-rhinitis study. Allergy. 2017 Jan 10. doi: 10.1111/all.13125. [Epub ahead of print]
  • Bousquet J, Hellings PW, Agache I, Bedbrook A, Bachert C, Bergmann KC, Bewick M, Bindslev-Jensen C, Bosnic-Anticevitch S, Bucca C, Caimmi DP, Camargos PA, Canonica GW, Casale T, Chavannes NH, Cruz AA, De Carlo G, Dahl R, Demoly P, Devillier P, Fonseca J, Fokkens WJ, Guldemond NA, Haahtela T, Illario M, Just J, Keil T, Klimek L, Kuna P, Larenas-Linnemann D, Morais-Almeida M, Mullol J, Murray R, Naclerio R, O'Hehir RE, Papadopoulos NG, Pawankar R, Potter P, Ryan D, Samolinski B, Schunemann HJ, Sheikh A, Simons FE, Stellato C, Todo-Bom A, Tomazic PV, Valiulis A, Valovirta E, Ventura MT, Wickman M, Young I, Yorgancioglu A, Zuberbier T, Aberer W, Akdis CA, Akdis M, Annesi-Maesano I, Ankri J, Ansotegui IJ, Anto JM, Arnavielhe S, Asarnoj A, Arshad H, Avolio F, Baiardini I, Barbara C, Barbagallo M, Bateman ED, Beghé B, Bel EH, Bennoor KS, Benson M, Białoszewski AZ, Bieber T, Bjermer L, Blain H, Blasi F, Boner AL, Bonini M, Bonini S, Bosse I, Bouchard J, Boulet LP, Bourret R, Bousquet PJ, Braido F, Briggs AH, Brightling CE, Brozek J, Buhl R, Bunu C, Burte E, Bush A, Caballero-Fonseca F, Calderon MA, Camuzat T, Cardona V, Carreiro-Martins P, Carriazo AM, Carlsen KH, Carr W, Cepeda Sarabia AM, Cesari M, Chatzi L, Chiron R, Chivato T, Chkhartishvili E, Chuchalin AG, Chung KF, Ciprandi G, de Sousa JC, Cox L, Crooks G, Custovic A, Dahlen SE, Darsow U, Dedeu T, Deleanu D, Denburg JA, De Vries G, Didier A, Dinh-Xuan AT, Dokic D, Douagui H, Dray G, Dubakiene R, Durham SR, Du Toit G, Dykewicz MS, Eklund P, El-Gamal Y, Ellers E, Emuzyte R, Farrell J, Fink Wagner A, Fiocchi A, Fletcher M, Forastiere F, Gaga M, Gamkrelidze A, Gemicioğlu B, Gereda JE, van Wick RG, González Diaz S, Grisle I, Grouse L, Gutter Z, Guzmán MA, Hellquist-Dahl B, Heinrich J, Horak F, Hourihane JO, Humbert M, Hyland M, Iaccarino G, Jares EJ, Jeandel C, Johnston SL, Joos G, Jonquet O, Jung KS, Jutel M, Kaidashev I, Khaitov M, Kalayci O, Kalyoncu AF, Kardas P, Keith PK, Kerkhof M, Kerstjens HA, Khaltaev N, Kogevinas M, Kolek V, Koppelman GH, Kowalski ML, Kuitunen M, Kull I, Kvedariene V, Lambrecht B, Lau S, Laune D, Le LT, Lieberman P, Lipworth B, Li J, Lodrup Carlsen KC, Louis R, Lupinek C, MacNee W, Magar Y, Magnan A, Mahboub B, Maier D, Majer I, Malva J, Manning P, De Manuel Keenoy E, Marshall GD, Masjedi MR, Mathieu-Dupas E, Maurer M, Mavale-Manuel S, Melén E, Melo-Gomes E, Meltzer EO, Mercier J, Merk H, Miculinic N, Mihaltan F, Milenkovic B, Millot-Keurinck J, Mohammad Y, Momas I, Mösges R, Muraro A, Namazova-Baranova L, Nadif R, Neffen H, Nekam K, Nieto A, Niggemann B, Nogueira-Silva L, Nogues M, Nyembue TD, Ohta K, Okamoto Y, Okubo K, Olive-Elias M, Ouedraogo S, Paggiaro P, Pali-Schöll I, Palkonen S, Panzner P, Papi A, Park HS, Passalacqua G, Pedersen S, Pereira AM, Pfaar O, Picard R, Pigearias B, Pin I, Plavec D, Pohl W, Popov TA, Portejoie F, Postma D, Poulsen LK, Price D, Rabe KF, Raciborski F, Roberts G, Robalo-Cordeiro C, Rodenas F, Rodriguez-Mañas L, Rolland C, Roman Rodriguez M, Romano A, Rosado-Pinto J, Rosario N, Rottem M, Sanchez-Borges M, Sastre-Dominguez J, Scadding GK, Scichilone N, Schmid-Grendelmeier P, Serrano E, Shields M, Siroux V, Sisul JC, Skrindo I, Smit HA, Solé D, Sooronbaev T, Spranger O, Stelmach R, Sterk PJ, Strandberg T, Sunyer J, Thijs C, Triggiani M, Valenta R, Valero A, van Eerd M, van Ganse E, van Hague M, Vandenplas O, Varona LL, Vellas B, Vezzani G, Vazankari T, Viegi G, Vontetsianos T, Wagenmann M, Walker S, Wang DY, Wahn U, Werfel T, Whalley B, Williams DM, Williams S, Wilson N, Wright J, Yawn BP, Yiallouros PK, Yusuf OM, Zaidi A, Zar HJ, Zernotti ME, Zhang L, Zhong N, Zidarn M. (2016) ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle. Clin Transl Allergy. 2016 Dec 30;6:47. doi: 10.1186/s13601-016-0137-4. eCollection 2016.
  • Guimarães M, Bugalho A, Oliveira AS, Moita J, Marques A; GI DPOC-Grupo de Interesse na Doença Pulmonar Obstrutiva Crónica. (2016) COPD control: Can a consensus be found? Rev Port Pneumol (2006). 2016 Mar 19. pii: S2173-5115(16)00014-2. doi: 10.1016/j.rppnen.2016.01.004. [Epub ahead of print]
  • Ana Mendes, Ana Luísa Papoila, Pedro Martins, Stefano Bonassi, Stefano Bonassi, Iolanda Caires, Teresa Palmeiro, Lívia Aguiar, Álvaro Silva Ribeiro, Cristiana Pereira, Paula Neves, Amália Botelho, Nuno Neuparth, João Paulo Teixeira. The Influence of Thermal Comfort in Older People Quality of Life. Submitted to Indoor Air (2015).
  • Teresa Baptista-Fernandes, Manuel Rodrigues, Dulce Domingues, Lucília Monteiro, Paulo Paixão, Patrícia Pereira, Raquel Tavares, Paulo Rodrigues, Isabel Maurício, Silvana Belo, Cristina Toscano. Dirofilariasis by Dirofilaria repens: an imported case and a brief review. Parasitology International. 2015; 64: 261-263.
  • Póvoa P, Martin-Loeches I, Artigas A. Biomarker Kinetics in VAP. Clinical Pulmonary Medicine 2015;22:185-191
  • Póvoa P, Salluh JIF. Corticosteroids in community-acquired pneumonia: What's the (end)point? The Lancet 2015;386:954
  • Paulo Paixão, Maria Jesus Chasqueira, Lúcia Rodrigues, Cátia Piedade, Iolanda Caires, Teresa Palmeiro, Amália Botelho, Madalena Santos, Maria José Silvestre, Martin Curran, Raquel Guiomar, Pedro Pechirra, Inês Costa, Ana Papoila, Nuno Neuparth. VIRAL ROLE IN ACUTE RESPIRATORY INFECTIONS IN ELDERLY CARE CENTERS. Submitted to The Journal of Gerontology (2015).
  • Pedro Carreiro-Martins, Joana Gomes-Belo, Ana Luísa Papoila, Iolanda Caires, Teresa Palmeiro, João Gaspar- Marques, Paula Leiria-Pinto, Ana Sofia Mendes, João Paulo-Teixeira, Maria Amália Botelho, Nuno Neuparth. Chronic Respiratory Diseases and Quality of Life in Elderlies. Submitted to Chronic Respiratory Disease (2015).
  • Ana Mendes, Ana Luísa Papoila, Pedro Martins, Stefano Bonassi, Iolanda Caires, Teresa Palmeiro, Lívia Aguiar, Cristiana Pereira, Paula Neves, Diana Mendes, Amália Botelho, Nuno Neuparth, João Paulo Teixeira. The Impact of Indoor Air Quality and Contaminants on Respiratory Health of Older People Living in Long-Term Care Residences in Porto. Journal Age and Ageing (2015). DOI 10.1093/ageing/afv157.
  • Martin-Loeches I, Póvoa P, Rodríguez A, Curcio D, Suarez D, Mira JP, Cordero ML, Lepec R, Girault C, Candeias C, Seguin P, Paulino C, Messika J, Gonzalez Castro A, Valles J, Coelho L, Rabello L, Lisboa T, Collins D, Torres A, Salluh J and Nseir S for the TAVEM study. Incidence and prognosis of Ventilator-Associated Tracheobronchitis: Results of the International TAVEM study. The Lancet Respiratory Medicine 2015;3:859-68
  • Araújo-Martins J, Martins PC, Viegas J, Aelenei D, Cano MM, Teixeira JP, Paixão P, Papoila AL, Leiria-Pinto P, Rosado-Pinto J, Annesi-Maesano I, Neuparth N. (2014). Environment and Health in Children Day Care Centers (ENVIRH) - Study rationale and protocol. Rev Port Pneumol 2014; Apr 16. pii: S0873-2159(14)00036-1. doi: 10.1016/j.rppneu.2014.02.006. [Epub ahead of print]
  • Carreiro-Martins P, Viegas J, Papoila AL, Aelenei D, Caires I, Araújo-Martins J, Gaspar-Marques J, Cano MM, Mendes AS, Virella D, Rosado-Pinto J, Leiria-Pinto P, Annesi-Maesano I, Neuparth N. (2014). CO2 concentration in day care centers is related to wheezing in attending children. Eur J Pediatr, Aug; 173(8): 1041­1049. DOI: 10.1007/s00431­014­2288­4. Epub 2014 Mar 4.
  • Gaspar-Marques J, Carreiro-Martins P, Papoila AL, Caires I, Pedro C, Araújo-Martins J, Virella D, Rosado-Pinto J, Leiria-Pinto P, Neuparth N. (2014). Food allergy and anaphylaxis in infants and preschool-age children. Clin Pediatr, 2014 March 18; 53 (7):652-657. DOI: 10.1177/0009922814527502.
  • Mendes A, Aelenei D, Papoila AL, Martins P, Aguiar L, Pereira C, Neves P, Azevedo S, Cano M, Proença C, Viegas J, Silva S, Mendes D, Neuparth N, Teixeira JP. (2014). Environmental and ventilation assessment in children day care centers in Porto: the ENVIRH project. J Toxicol Environ Health A.; 77:14-16, 931-943, DOI: 10.1080/15287394.911134
  • Paixão P, Piedade C, Papoila A, Caires I, Pedro C, Santos M, Silvestre MJ, Brum L, Nunes B, Guiomar R, Curran MD, Carvalho A, Marques T, Neuparth N. (2014). Improving influenza surveillance in Portuguese preschool children by parents´ report. Eur J Pediatr, Aug; 173(8):1059­65. DOI: 10.1007/s00431­014­2285­7. Epub 2014 Mar 6.
  • Mota P, Silva HC, Soares MJ, Pego A, Loureiro M, Cordeiro CR, Regateiro FJ. Genetic polymorphisms of phase I and phase II metabolic enzymes as modulators of lung cancer susceptibility. J Cancer Res Clin Oncol. 2014;141(5):851-60
  • Sá-Sousa A, Jacinto T, Azevedo LF, Morais-Almeida M, Robalo-Cordeiro C, Bugalho-Almeida A, Bousquet J, Fonseca JA. Operational definitions of asthma in recent epidemiological studies are inconsistent. Clin Transl Allergy. 2014, 4;4:24
  • Martins P.C., Valente J., Papoila A.L., Caires I., Araújo-Martins J., Mata P., Lopes M., Torres S., Rosado-Pinto J., Borrego C., Annesi-Maesano I., Neuparth N. (2012). Airways changes related to air pollution exposure in wheezing children. Eur Respir J, Feb; 39(2):246-253. doi: 10.1183/09031936.00025111. Epub 2011 Jun 30.
  • Martins P, Pinto RP, do Céu Teixeira M, Neuparth N, Silva O, Tavares H, Spencer JL, Mascarenhas D, PapoilaAL, Khaltaev N, Annese-Maesano I .Under-report and underdiagnosis of chronic respiratory diseases in An African country. Allergy. 2009 Jul;64(7):1061-7.
  • Borrego, L, Stocks, J, Leiria-Pinto, P, Peralta, I, Romeira, AM, Neuparth, N, et al. Lung function and clinical risk factors for asthma in infants and young children with recurrent wheeze. Thorax. 2009 Mar;64(3):203-9. Epub 2008 Nov 13.
  • Fleming DM, Crovari P, Wahn U, Klemola T, Schlesinger Y, Langussis A, Øymar K, Garcia ML, Krygier A, Costa H, Heininger U, Pregaldien JL, Cheng SM, Skinner J, Razmpour A, Saville M, Gruber WC, Forrest B; CAIV-T Asthma Study Group. Comparison of the efficacy and safety of live attenuated cold-adapted influenza vaccine, trivalent, with trivalent inactivated influenza virus vaccine in children and adolescents with asthma. Pediatr Infect Dis J. 2006 Oct;25(10):860-9.
  • Ramos, A.P., Marques, M.J., Fabião, A., Todo-Bom, A., Fontes, L., Neuparth, N., Santos-Pereira, J. e Lopes da Mata, P. Concentration of airborne pollen from Cupressaceae in Lisbon. Allergie & Immunologie 2000; 32(3), 109-110.
  • Neuparth N, Gamboa T, Pereira C, Rosado Pinto J, Rendas A. Budesonide reverses lung hyperinflation in childhood asthma. A controled study. Pathophysiology 1999; 6:199-204.
  • Morais de Almeida, M., Rosado Pinto, J. Bronchial asthma in children: clinical and epidemiologic approach in different portuguese speaking countries. Pediatric Pulmonology 1999, 27(suppl.18): 49-53.
  • Kharitonov S, Alving K, Barnes PJ. Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force. Eur Respir J. 1997; 10(7): 1683-1693.
  • Gamboa T, Neuparth N, Ribeiro da Silva I, Pinto JE, Rendas AB. Methacholine dose-response slopes from maxila bronchial challenge tests in asthmatic children: methodological aspects. Lung. 1997;175(4):243-252.

Publications in National Peer-Reviewed Journals

  • Araújo Gonçalves P, Jerónimo Sousa P, Cale R, Marques H, Santos MB, Dias A, Dores H, Carvalho MS, Ventosa A, Martins T, Teles R, Almeida M, Mendes M. Effective radiation dose of three diagnostic tests in cardiology: single-photon emission computed tomography, invasive coronary angiography and cardiac computed tomography angiography. Rev Port Cardiol 2013; 32(12): 981-6.
  • Leal S, Campante Teles R, Calé R, Sousa PJ, Brito J, Raposo L, Araújo Gonçalves P, Baptista J, Sousa Almeida M, Silva A, Mendes M; ACROSS Registry Investigators. Percutaneous revascularization strategies in saphenous vein graft lesions: long-term results. Rev Port Cardiol 2012 Jan;31(1):11-8. IF 0.53
  • P. Araújo Gonçalves, M. de Sousa Almeida, P. Branco, A. Gaspar, A. Weigert, J. D. Barata, A. Canha Gomes, L. Raposo; H. Mesquita-Gabriel, R. Campante Teles; M. Mendes. Ablação da actividade simpática renal para tratamento da hipertensão arterial resistente. Rev Port Cardiol 2012; 31(10):671-675.
  • Martins P., Valente J., Papoila A.L., Caires I., Araújo-Martins J., Mata P., Lopes M., Torres S., Rosado-Pinto J, Borrego C., Neuparth N. (2012). Efeito conjunto da exposição à poluição do ar e aos ácaros do pó, sobre as vias aéreas [Combined effect of air pollution and house dust mite exposure over the airways]. Rev Port Imunoalergologia, 20(1): 47-57. (1º classificado do Prémio SPAIC – Bial Aristegui 2011).
  • Miguel Paiva, Pedro Martins, Susana Carvalho, Marta Chambel, Anália Matos, Isabel Almeida, Ana Luísa Papoila, Nuno Neuparth, Paula Leiria Pinto. Avaliação do controlo da asma: Utilização de diferentes métodos. Rev Port Imunoalergologia 2010; 18 (3): 227-241.
  • Martins P., Caires I., Pinto J.R., Lopes da Mata P., Torres S., Valente J., Borrego C., Neuparth N. (2008). Medição do óxido nítrico no ar exalado: Utilização na avaliação de crianças com história de sibilância [The clinical use of exhaled nitric oxide in wheezing children]. Rev Port Pneumol, XIV (2): 195-218.
  • Nuno Neuparth. Asma: Porquê e quando pedir uma avaliação funcional respiratória. Respir´AR, 2007;4:15-16.
  • Martins P, Neuparth N, Silva M, Lopes da Mata P. Futebol e doença alérgica respiratória. Rev Port Imunoalergologia, 15 (2): 151-161; 2007.
  • Luís Miguel Borrego, Paula Leiria Pinto, Nuno Neuparth, José Rosado Pinto. A Criança com Dificuldade Respiratória: Importância do Laboratório de Exploração Funcional Respiratória. Revista Nascer e Crescer, 2006;15(3):S153-158.
  • Luís Miguel Borrego, Paula Leiria Pinto, Nuno Neuparth, José Rosado Pinto. Espirometria Pré-escolar: estudo de uma população - que implicações? Rev Port de Imunoalergologia 2005;13(3):225-31.
  • Filomena Neves, Pedro Lopes da Mata, Nuno Neuparth. Ácaros, casa e doença alérgica. Rev Port Imunoalergologia 2005;13(4):367-376.
  • Luís Miguel Borrego, Paula Leiria Pinto, Nuno Neuparth, José Rosado Pinto. Função respiratória na criança em idade pré-escolar. Rev Port de Imunoalergologia 2004; 12: 367-372.
  • Bugalho, A, Neuparth, N. Association between bronchial reversibility and airway inflammation in patients with chronic obstructive pulmonary disease. Rev Port Pneumol 2002; VIII (6): 547-580.
  • Mário Morais de Almeida, Ângela Gaspar, Paula Leiria Pinto, Anália Matos, Nuno Neuparth, José Rosado Pinto. Asma de esforço na criança - Contributos para a normalização das provas de provocação Rev Port Imunoalergologia 2001; 8(4):217-228.
  • Mário Morais de Almeida, Ângela Gaspar, Ana Romeira, Graça Sampaio, Céu Teixeira, Rita Câmara, Ana Marques, Dulce Lopes, Kim Mui Ieong, Isabel Andrade, Nuno Andrade, Cristina Santa Marta, Graça Pires, Jorge Romeira, Nuno Neuparth, Fernando Drummond Borges. "Reactividade cutânea inespecífica em estudos populacionais" Rev Port Imunoalergologia 2001; 8(4):199-204.
  • Araújo Gonçalves P., Lopes da Mata P., Neuparth N., Rendas A. Papel do óxido nítrico como marcador de inflamação em doenças respiratórias. Rev Port de Pneumologia 2000; VI(4): 309-318.
  • Neuparth N, Araújo Gonçalves P., Bugalho de Almeida A, Rendas A. "Asma e leucotrienos". Rev Port de Pneumol 1999; V(5):487-497.
  • Nuno Neuparth. Epitélio - Actor ou Cenário na Inflamação Alérgica: Óxido Nítrico. Rev Port Imunoalergologia 1998; 6(2):144-145.
  • T Gamboa, J. Rosado Pinto, N. Neuparth, A. Rendas. Obstrução brônquica máxima induzida em crianças asmáticas: análise dos indicadores de susceptibilidade brônquica aumentada à metacolina. Rev Port Pneumol 1997;1:5-37.
  • M. Van Schie, T. Gamboa, C.S. Pereira, N. Neuparth, J.E. Rosado Pinto, A.B. Rendas. Calibração de nebulizadores usados em testes de provocação brônquica. Arquivos da Sociedade Portuguesa de Patologia Respiratória 1994;11(2):89-94.
  • Neuparth N, Gamboa T, Morais de Almeida M, Ribeiro da Silva I, Matos A, Rosado Pinto JE, Rendas AB. Estudo comparativo de vários estímulos não específicos da hiperreactividade brônquica em crianças asmáticas. Arquivos da Sociedade Portuguesa de Patologia Respiratória 1992; 9(1):5-12.
  • Neuparth N. Hiperinsuflação na criança asmática. Cadernos de Imuno-Alergologia Pediátrica 1991; 6(Supl): 81-83.
  • Neuparth N. Os testes de provocação brônquica farmacológicos. Boletim da Sociedade Portuguesa de Patologia Respiratória 1991;13:19-21.
  • Neuparth N Pereira C, Gamboa T, Moura Pires F, Rosado Pinto JE, Bensabat Rendas A. Será o Peak Flow válido como parâmetro de monitorização da obstrução brônquica em testes de provocação? Cadernos de Imuno-Alergologia Pediátrica 1990; 5(2):5-10.
  • Neuparth N. Novos métodos de avaliação funcional respiratória na criança. Cadernos de Imuno-Alergologia Pediátrica 1989; 4(Supl):139-141.
  • Neuparth N, Gamboa T, Pereira C, Rosado Pinto JE, Bensabat Rendas A. Teste de provocação brônquica com metacolina em crianças asmáticas: standardização do método com um dosímetro. Arquivos da Sociedade Portuguesa de Patologia Respiratória 1988; V(2):7-15.
  • Roxo Neves P, Mota Carmo M, Neuparth N, Dall’va Santucci J, Bensabat Rendas A. Análise da frequência respiratória durante a vigília em indivíduos saudáveis. Arquivos da Sociedade Portuguesa de Patologia Respiratória 1988; V(1):65-70.

Books & Book Chapters

  • J. P. Teixeira, A. Botelho, N. Neuparth, I. Caires, A. Papoila, P. Martins, P. Paixão, D. Aelenei, J. Viegas, M. Cano, A. Mendes (Eds). Geriatric Study in Portugal on Health Effects of Air Quality in Elderly Care Centers. Instituto de Saúde Pública - Universidade do Porto, Porto, 2015. ISBN: 978-989-98867-7-3
  • Ana Mendes, Pedro Martins, Ana Luísa Papoila, Iolanda Caires, Teresa Palmeiro, Lívia Aguiar, Cristiana Pereira, Paula Neves, Amália Botelho, Nuno Neuparth, João Paulo Teixeira. Quality of Life in: J. P. Teixeira, A. Botelho, N. Neuparth, I. Caires, A. Papoila, P. Martins, P. Paixão, D. Aelenei, J. Viegas, M. Cano, A. Mendes (Eds). Geriatric Study in Portugal on Health Effects of Air Quality in Elderly Care Centers. Instituto de Saúde Pública - Universidade do Porto, Porto. Cap 5: 37-43, 2015. ISBN: 978-989-98867-7-3
  • Borrego C, Carvalho A, Miranda AI, Costa AM, Monteiro A, Amorim JH, Valente J, Lopes M, Neuparth N. Investigação em Ambiente e Saúde - desafios e estratégias; Universidade de Aveiro, 2009.
  • Borrego C., Neuparth N., Carvalho A.C., Carvalho A., Miranda A.I., Costa A. M., Monteiro A., Martins H., Correia I., Ferreira J., Amorim J.H., Martins J., Pinto J.R., Santos J., Silva J.V., Valente J., Simões L., Lopes M., Tchepel O., Cascão P., Lopes da Mata P., Martins P., Santos P., Tavares R., Nunes T., Martins V. (2008). A Saúde e o Ar que Respiramos – um caso de estudo em Portugal. Textos de Educação. Lisboa. Fundação Calouste Gulbenkian. ISBN: 978-972-31-1259-7.
  • C. Borrego, M. Lopes, J. Valente, J. Santos, T. Nunes, H. Martins, A. I. Miranda & N. Neuparth. Air pollution and child respiratory diseases: the Viseu case study, Portugal. In Brebbia, CA ed. Air Pollution XV. pp:15-24, 2007.
  • Rosado Pinto J, Morais de Almeida M, Neuparth N, Teixeira MC, Vieira Lopes D, Andrade I, Andrade N, Humberto J. Experiência de Cooperação em Cabo Verde e Macau. In Rosado Pinto, J e Morais de Almeida, M ed. - A criança asmática no mundo da alergia. 6ª secção, Cap. 69:517-522, 2003.
  • Neuparth, N. Avaliação funcional respiratória na criança asmática. In Rosado Pinto, J e Morais de Almeida, M ed. - A criança asmática no mundo da alergia. 2ª secção. Cap. 17:129-135, 2003.
  • Mata JP, Cardos AP, Ferreira JR, Neuparth N, Sá RC. Estudo funcional em situações particulares. Cap. 15.3. Secção D In Gomes, MJM e Sotto-Mayor R, ed. – Tratado de Pneumologia. Lisboa, 2003.
  • Neuparth N. Broncomotricidade e inflamação brônquica. Cap. 14. Secção D In Gomes, MJM e Sotto-Mayor R, ed. – Tratado de Pneumologia. Lisboa, 2003.
  • Neuparth N, Ferreira JR, Cardoso AP, Matos MJ, Bárbara C, Rodrigues F. Avaliação funcional respiratória. Cap. 10.1 a 10.4. Secção D In Gomes, MJM e Sotto-Mayor R, ed. – Tratado de Pneumologia. Lisboa, 2003.
  • Neuparth N. Qual é a relação entre inflamação e hiperreactividade brônquica? Cap. 6. In Gomes, MJM e Sotto-Mayor R, ed. - Especialistas falam-lhe sobre asma brônquica. Lisboa, 1999.
  • Neuparth N. Efeito dos corticoides sobre a hiperreactividade brônquica. In Segorbe Luís A. A corticoterapia na asma brônquica. Cap. 6:89-97. Lisboa, 1998.
  • Neuparth N. A avaliação funcional respiratória da criança: relato da experiência do Laboratório de Exploração Funcional da Unidade de Imunoalergologia do Hospital de Dona Estefânia. in: JE Rosado Pinto ed. A Criança Asmática, Glaxo Farmacêutica, 2ª edição, 1993.
  • Neuparth N, Bensabat Rendas A. Fisiopatologia da asma. in JE Rosado Pinto ed. A Criança Asmática, Glaxo Farmacêutica, 1988.

Publications in National Scientific Meeting Acta

  • Martins P., Lopes da Mata P., Monteiro S., Caires I., Pinto J.R., Valente J., Borrego C., Neuparth N. (2007) Projecto Saud’Ar: Caracterização acarológica de ambientes interiores. Actas da 9ª Conferência Nacional de Ambiente, 18-20 Abril, Aveiro (1): 148-153.
  • Borrego C., Neuparth N., Valente J., Martins P., Correia I., Ferreira J., Lopes M., Santos J. (2007) Avaliação da exposição de crianças a poluentes atmosféricos e relação com marcadores de inflamação respiratória. Actas da 9ª Conferência Nacional de Ambiente, 18-20 Abril, Aveiro (1): 127-134.
  • Borrego C., Neuparth N., Valente J., Santos J., Lopes M., Ferreira J., Nunes T., Miranda A.I., Amorim J.H., Santos P., Carvalho A.C., Carvalho A., Costa A.M., Monteiro A., Martins H., Martins V., Tavares R., Mata P., Martins P., Correia I., Pinto J.R., Monteiro S., Pinho P., Lemos L., Simões L. (2007) Projecto SaudAR: A Saúde e o Ar que Respiramos. Actas da 9ª Conferência Nacional de Ambiente, 18-20 Abril, Aveiro (4): 1182-1186.

Collaborations

- Antonio Artigas, Sabadell Hospital - Universidade Autonoma de Barcelona, Spain

- Ignacio Martin Loeches, St James's University Hospital, Ireland

- Jose Miguel Martins, Instituto Superior Técnico, University of Lisbon (IST-UL), Portugal

- Paulo Ribeiro, Faculty of Sciences and Technology, New University of Lisbon (FCT-UNL), Portugal

Team photos