Immune cells must exchange and store information in the course of searching for and responding to disease. This information exchange is relayed through specialized membrane receptors that initialize signaling cascades, which culminate in the production of immune mediators responsible for disease resolution.
On the T cell this information is received through a specific membrane receptor - the T cell receptor- that is responsible for integrating the information relayed through a signaling cascade that culminates in the production of immune mediators that will clear the infection.
Overall, our lab is interested in determining how immune receptor signaling is able to convey distinct immune responses that protect us against disparate aggressions (fungus, virus, bacteria, cancer, etc.).
Our current research is comprised of three interconnected axis:
1- To establish how signaling architecture regulates immune responses;
2- To determine how alterations in signaling lead to auto-immunity;
3- To decipher how pathogens (HIV-1) exploit the immune signaling to their own advantage.
We use tissue samples from patients, as a privileged disease model, to investigate the role of anomalous T signaling in the chronic immune activation underpinning immunodeficiency and auto-immune diseases. We combine immune physiology, cell biology and signaling with super-resolution microscopy approaches to determine the molecular and cellular mechanisms involved and to identify genes and signaling pathways implicated.
Our final goal is to identify biomarkers and molecular targets that will enable for the development of novel therapies.
- Human Immune Physiology
- Signaling architecture and High-resolution imaging
- Investigador FCT 2014-2019
- ANRS (French AIDS Research Foundation) Grant: 2013-2015
- Silva JG, Martins NP, Henriques R, Soares H. (2016) HIV-1 Nef Impairs the Formation of Calcium Membrane Territories Controlling the Signaling Nanoarchitecture at the Immunological Synapse.. Journal of Immunology. 2016. 197 (10): 4042-4052; selected to be highlighted “In this Issue” of The Journal of Immunology
- Soares H*. HIV-1 intersection with CD4 T cell vesicle exocytosis: intercellular communication goes viral. Frontiers in Immunology. 2014. 5:454 doi: 10.3389/fimmu. (*Corresponding author)
- Soares H, Lasserre R, Alcover A. Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses. Immunological Reviews. 2013. 256(1): 118-13
- Soares H*, Henriques R, Ventimiglia L, Alonso MA, Zimmer C, Thoulouze MI, Alcover A*. A regulated vesicle fusion cascade generates signaling nanoterritories that control T-cell activation at the immunological synapse. Journal of Experimental Medicine. 2013. 210(11): 2415-33. Selected for 1000Prime as being of special significance in its field; highlighted on Journal of Cell Biology and on Journal of General Physiology (*Corresponding authors)
- Herbert S, Soares H, Zimmer C, Henriques R. Single-molecule super-resolution microscopy: deeper and faster. Microscopy and Microanalysis. 2012. 18(6): 1419-29
- Soares H, Waechter H, Glaichenhaus N, Mougneau E, Yagita H, Mizenina O, Dudziak D, Nussenzweig MC, Steinman RM. A subset of Dendritic cells induces CD4+ T cells to produce IFN- by an IL-12-independent but CD70-dependent mechanism in vivo. J. Exp. Med. 2007. 204 (5): 1095-1106
- Trumpfheller C, Finke JS, Lopez CB, Moran TM, Moltedo B, Soares H, Huang Y, Schlesinger SJ, Park CG, Nussenzweig MC, Granelli-Piperno A, Steinman RM. Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. J. Exp. Med. 2006. 203 (3): 607-617
- Bonifaz LC, Bonnyay DP, Charalambous A, Darguste DI, Fujii S, Soares H, Brimmes MK, Moltedo B, Moran TM, Steinman RM. In vivo targeting of antigens to maturing dendritic cells via DEC-205 receptor improves T cell vaccination. J. Exp. Med. 2004. 199(6): 815-824
- Andrade LCR, Paixão JA, de Almeida MJM, Martins RML, Soares HIM, Moreno MJSM, Sá e Melo ML, Campos Neves AS. 16, 17-Epoxy-20-oxopregn-5-ene-3b, 21-diyl diacetate. 2003. Acta Crystallogr. (E) E59: 299-301.
- Andrade LCR, Paixão JA, de Almeida MJM, Martins RML, Soares HIM, Moreno MJSM, Sá e Melo ML, Campos Neves AS. 16-Hydroxi-20-oxopregn-5-en-3-yl acetate. 2001. Acta Crystallogr. (E) E57: 571-57
- Andrade LCR, Paixão JA, de Almeida MJM, Martins RML, Soares HIM, Morais GJR, Moreno MJSM, Sá e Melo ML, Campos Neves AS. 1617-Epoxi-20-oxopregn-5-en-3-yl acetate. 2001. Acta Crystallogr. (C1) C57: 587-589
Jaime Branco- Rheumatological Diseases unit, CEDOC/FCM, Lisbon, Portugal
Margarida Serrado- Hospital Pulido Valente, CHLN
Ricardo Henriques- Quantitative Imaging and NanoBioPhysics Group, UCL, London, UK
Paula Videira- Laboratory of Glycoimmunology, Faculdade de Ciências e Tecnologia, Caparica, Portugal
Robert Weil- Laboratory of Signaling and Pathogenesis, Institut Pasteur, Paris, France
We welcome motivated technicians, students (undergraduates, master and PhD) and post-docs to join our lab. For enquiries on available positions contact Helena Soares (helena.soares(at)nms.unl.pt). Please add a letter detailing the reasons you are applying, your CV, and contact information of 3 references.