DysBrainD: Dysmetabolism in Brain Diseases

hugo v miranda 2

Hugo Vicente Miranda

Principal Investigator
[2014-2018] Post-Doc - Cell and Molecular Neurosciences in CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, Universidade NOVA de Lisboa
[2010-2017] Post-Doc - Cell and Molecular Neurosciences in Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa
[2006-2010] PhD in Biochemistry – Metabolic Regulation in Faculdade de Ciências da Universidade de Lisboa
[2000-2005] Pre-Bologna Licenciate Degree – Biochemistry in Faculdade de Ciências da Universidade de Lisboa

CV

 

Location:

CEDOC
Campus Sant'Ana
Pólo de Investigação, NMS, UNL
Rua Câmara Pestana, nº 6
Lab 3.8
1150-082 Lisboa, Portugal

Phone: (+351) 218 803 101 (Ext. 26071)
Lab ext: 26040
Fax: (+351) 218 851 920
E-mail: hmvmiranda(at)nms.unl.pt

Main Interests:

Our research relies in the hypothesis that brain dysmetabolism is an underlying cause of neurodegenerative diseases such as Parkinson’s or Alzheimer’s.
Epidemiological findings suggest that dysmetabolism such as in Diabetes is an important risk factors for neurodegenerative diseases. Importantly, we identified that protein glycation, a major consequence of hyperglycemia, is a molecular link between these disorders. Therefore, we are focused in understanding how sugar stress potentiates neurodegeneration. This will ultimately allow to identify novel therapeutic targets for brain diseases.

esquema glycation

 
 

Research Areas:

Our primary questions are:
1. What is the impact of diabetes (hyperglycemia) in brain diseases?
2. What are the effects of dysbiosis in Parkinson’s disease?
3. Are glycation defenses putative therapeutic agents for Parkinson’s disease?
4. What are the major proteome response mechanisms to glycation in models of brain diseases?

 
 

Experimental Systems:

1. in vitro systems – cell and molecular biology techniques
2. mouse models of the diseases - effects of normo/hypercaloric diets in mice
3. Proteomics and genetic approaches

hvm_aims2

 
 

Discover more about the DysBrainD: Dysmetabolism in Brain Diseases Lab:

- Doença de Parkinson deixa marcas numa proteína no sangue
- Biomarcadores para a doença de Parkinson | Biomarkers for Parkinson's Disease

 
 
 

2018-2019 – Sugar stress in the brain, Sociedade Portuguesa de Diabetologia, Portugal
(PI: Hugo Vicente Miranda)

2018 - 2020 - Sugar stress in the brain, iNOVA4Health, Portugal
(PI: Hugo Vicente Miranda, Co-PIs: Ricardo Gomes, iBET; Tiago Outeiro, CEDOC)

2016 - 2019 - Targeting the glycation defenses as a protective strategy for Parkinson’s disease, Fundação para a Ciência e Tecnologia, Portugal
(PI: Hugo Vicente Miranda)

2013/2014 - Alpha-synuclein as blood biomarker for Parkinson's Disease, Fundação para a Ciência e Tecnologia, Fundação para a Ciência e Tecnologia, Portugal
(PI: Hugo Vicente Miranda)

Selected Publications:

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Collaborations

• Maria Paula Macedo (Aveiro University, Portugal)
• Tiago Fleming Outeiro (CEDOC, NMS|FCM, UNL, Portugal & • Gottingen Medical School, Germany)
• Luísa V. Lopes (iMM, Portugal)
• Maria José Diógenes (iMM, Portugal)
• Patrícia Gomes-Alves & Ricardo Gomes (iBET, Portugal)
• Manuel Santos (Aveiro University, Portugal)
• Bruno Costa-Silva (Champalimaud Foundation, Portugal)
• Joaquim Ferreira & Leonor Correia-Guedes (iMM, Portugal)
• Flaviano Giorgini (Leicester University, UK)
• Wei-Xiang (FAU, Germany)
• Rune Matthiesen (CEDOC, NMS|FCM, UNL)

 
 

Team photos

foto team 2

foto team 1

 
 

Motivated students (Undergraduate, Master and PhD) are encouraged to apply. Interested candidates, please send your CV, a letter explaining your interests and the name/contact information for 1-3 references to Hugo Vicente Miranda (hmvmiranda(at)nms.unl.pt).