EpiDoc Unit – Epidemiology of Chronic Diseases and Health Innovation

helena canhao 2

Helena Canhão

EpiDoc Unit Coordinator and Group Leader
Graduated in Medicine - Faculdade de Medicina, University of Lisbon
Master in Clinical Research - Harvard Medical School, Harvard University, Boston, USA
PhD in Medicine (Rheumatology) – Faculdade de Medicina, University of Lisbon
Habilitation in Medicine (Rheumatology) - Faculdade de Medicina, University of Lisbon

Brief CV



Campus Sant'Ana
Pólo de Investigação, NMS, UNL
Rua do Instituto Bacteriológico, nº 5
Lab 2.20B
1150-082 Lisboa, Portugal

Phone: (+351) 218 803 110
Ext: 27002/6
Lab ext: 27016
Fax: (+351) 218 851 920
E-mail: helena.canhao(at)nms.unl.pt

Main Interests:

EpiDoC is an epidemiology and outcomes research unit promoted by NOVA Saude and located in NOVA Medical School - CEDOC aiming at providing scientific information of excellence, gathering health and diseases issues and covering clinical, social, economic and human aspects.
Our major research focus is on clinical epidemiology and outcomes research. Even though the largest research interest is on chronic non-communicable diseases, other areas are also developed in partnership with ENSP and ITQB namely public health and molecular epidemiology.
Large experience in training and mentoring of master, doctoral and post-doctoral students are also a Unit’s major activity.
This Unit has expertise in surveys, chronic disease registries, observational studies and management of large databases including a wide range of data: demographic, life habits, clinical, pharmacological, socio-economic, labor, quality of life (QoL), imaging, genetic and laboratorial data.
We have been made long term investment in a population based longitudinal cohort with imaging and blood samples.
EpiDoC is also dedicated to help patients and vulnerable population groups to improve their health. We are committed on promoting educational and training strategies using information and communications technology (ICT, internet, apps and smart TV tools). The Unit has also experience in conducting interventional studies using these new ICTs.
Our aim is to contribute to patient empowerment, to reduce inequities in health and to provide evidence for public health policies.

Main goal
To promote and develop epidemiological and clinical research at NOVA University

Specific Objectives
1- Promote and develop synergies with other research groups (CEDOC, ENSP, ITQB)
2- Promote and boost ongoing research projects (EpiReumaPt, CoReumaPt and Saude.Come)
3- Increment successful call applications (H2020, FCT, other)
4- Develop educational activities (workshops, courses, training, book of epidemiology)

1) Epidemiological studies and research projects’ design and development
EpiDoC is prepared to give assistance with the preparation of research designs and development of research studies: conceptualize the research problem, develop protocols, study design selection, study setting, exposure definition and measurement, outcome definition and measurement, covariate and data sources selection, sample size and power calculations.

2) Ongoing projects and data availability
EpiDoC is following since 2011, 10661 subjects representative of the Portuguese population (EpiReumaPt & CoReumaPt), capturing several health dimensions.
We are leading the project “Saúde.Come” that aims to create valid information on food insecurity in Portugal with the partnership of ISPUP, NTNU, CLSBE and SPR. This project is conducting a national register on Food Insecurity and performing a randomized control trial (RCT) using new information and communication technologies (ICT) such as apps, online platforms and interactive TV for vulnerable groups.

All data is available for researchers by submitting research projects to the scientific committee.
The unit develops studies in diverse areas mainly in non-communicable chronic diseases. We have the ability to cover large, diverse, defined populations selected for a particular disease, condition, or procedure, capturing complete clinical information about this population over time, including longitudinal information on clinical care, changes in clinical characteristics and conditions, and assessment of clinical care services and outcomes in health.

3) Biological samples & Imaging data
The unit holds biological samples (serum and DNA) and imaging data (DXA and X-rays hip, knee, hand and spine) from over 3,600 donors, enabling and encouraging studies of this kind.

4) Information and communication technologies in health
Developing new technologies (internet, apps, smart TV) as tools to improve health and to monitor disease.
We are design and apply online platforms, apps and TV programs to collect objective measures and clinical monitoring refining individual follow-up of chronic disease patients. These tools are also applied as educational and motivation tools as well as in interventional studies namely to promote life healthy habits.

5) Training and educational activities
This unit allows researchers (fellows, trainees, pre and post graduate students, doctoral and postdoctoral students, etc.) to access database information and facilities including training in epidemiology and cohort study design, dataset cleaning, analysis and interpretation. The Unit endorses mentorship, regular seminars, scientific courses and hands-on workshops to assure high quality research training.

6) Public Health promotion and community intervention
The aim of this activity is to promote the health of the Portuguese population by developing, implementing, and evaluating health promotion/disease prevention programs. Priority areas include non-communicable chronic diseases (rheumatic, cardiovascular, metabolic, dermatologic, gastrointestinal, neurologic and respiratory) but also oncological and infectious diseases.
Community intervention for health is designed to develop and showcase sustainable interventions and policies that improve health and prevent disease in communities.
It demonstrates the effectiveness of healthy lifestyles in non-communicable chronic diseases prevention in a way that is both practical and scientifically rigorous.
Campaigns, reports, papers, meetings, holiday’s camps are promoted to increase the awareness and knowledge on chronic diseases and public health. Direct and web support to investigators and community are offered.

The unit promotes research networking, both national and international, as well as develops collaborative projects. Data from our cohorts and projects are available for researchers by submitting research projects to the scientific committee.

EpiDoC Unit Flyer

Variables available for research studies proposals

• To develop, test and apply innovative forms of “measure” health condition in patients with chronic diseases through new technologies such as internet, apps, smart TV, using patient oriented strategies;
• To identify health access and health consumption inequalities among individuals;
• To identify predictors of morbidity and mortality among non-communicable chronic diseases;
• To study the influence of clinical and socio-demographic and life style characteristics in health outcomes in the Portuguese population;
• To determine the burden of different non-communicable chronic diseases on the functional capability, work status, social and economic outcomes;
• To contribute to outcomes research of multiple diseases including the identification of biomarkers for disease susceptibility, activity and severity, encouraging the development of new approaches to prevention, diagnosis and treatment;
• To monitor the effectiveness and safety of chronic diseases’ treatments in a "real-world" setting;
• To provide community services in the prevention, detection and treatment of chronic diseases and in the education of the population.

epidoc rodas dentadas


1) Lisbon AHA, Reference Site, EIP-AHA (Helena Canhão)

2) PIC 4 COVID-19, Plano Individual de Cuidados (Manuel José Lopes)

3) Fast Track COVID (Maria José de Sousa)

4) OSCAR – vOice Screening of CoronA virus (Nuno Neuparth)

5) MyBack – Effectiveness and implementation of a tailored self-management programme to prevent recurrences and disability and promote musculoskeletal health in Low Back Pain patients (Eduardo Cruz)

6) EpiDoC 4 - Non communicable chronic diseases during COVID-19 pandemic (Ana Rodrigues and Helena Canhão)

7) COTIDIANA - Mobile Patient-centered System to Improve Drug Trials and Care of Older-adults with Rheumatic Diseases

8) Improving Osteoporosis Treatment Adherence using ICTs: The Healthy Bone Program (Ana Rodrigues)
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9) Revolutionizing Healthcare: Empowering patients by valuing innovation and promoting entrepreneurship: Patient2Entrepreneurship (P2E) (Helena Canhão)

10) CheckAP – Prevalence of Psoriatic Arthritis (PsA) and performance evaluation of a PsA screening Questionnaire in the population of Portuguese patients with Psoriasis followed in a Dermatology setting

11) PORTHOS – PORTuguese Heart failure Observational Study

12) Performance of rheumatoid arthritis disease activity instruments in distinct populations - a comparative study upon METEOR (Helena Canhão)

13) Risk of fragility fractures and falls in the Portuguese diabetic population (Sofia Furtado)

14) ReumaHEART - a Portuguese population-based study (Vital Domingues)
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15) Anxiety and depression in Portuguese elderly – determinants and impacts (Rute Dinis de Sousa)

16) FLEPIPORT – Investigating the association of fluoride in drinking water in the epidemiology of skeletal ectopic calcifications and bone fragility in Portugal (Jácome Armas)

17) Food insecurity in Portugal – costs, burden, challenges and implications (Helena Canhão and Julian Perelman)
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18) SAICT-POL/23439/2016 [LISBOA-01-0145-FEDER-023439] - SPLIT - Tratamento estratificado para indivíduos com dor lombar nos cuidados de saúde primários (Helena Canhão and Eduardo Cruz)
projeto HC split

19) Patient2Entrepreneur - Revolutionizing Healthcare: Empowering patients by valuing innovation and promoting entrepreneurship (Helena Canhão and Pedro Oliveira)

20) Patient Innovation Bootcamp: Boosting Patient Entrepreneurship (Helena Canhão and Pedro Oliveira)

21) Patient Innovation (Helena Canhão and Pedro Oliveira)
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22) PREDICT - Personalized therapy for RhEumatic DIseases via machine learning (Helena Canhão and Alexandra Carvalho)

23) FrailCare.AI – Intelligent frailty pathways for the Portuguese elderly population and impact analysis of the telecare service SNS24 Proximidade Sénior (Helena Canhão)

24)PrevOcupAI - Prevention of occupational disorders in public administration based on artificial intelligence (Helena Canhão and Hugo Gamboa)

25) LEAVES – Optimizing the mental health and resilience of older adults that have lost their spouse via blended, online therapy (Helena Canhão)


26) InDEPENDEnt – Impact of Dietary Protein on Disability in ageing Europeans (Nuno Mendonça)

27) The burden and costs of refractory depression

28) ARtificial Intelligence for BOne functioning Simulation – ARIBOS (Ana Rodrigues)

29) “No + Fracture” Portugal Fracture Clinics Network Implementation (Ana Rodrigues and Helena Canhão)

30) PAASPORT - Prevalence, patient characteristics and patient’s quality of life – understanding the impact associated to psoriatic arthritis and ankylosing spondylitis in Portugal (Ana Rodrigues and Helena Canhão)

31) Osteoarthritis and Adherence to Mediterranean Diet (Ana Rodrigues and Mário Farinhó)

32) Sleep duration and association upon rheumatic diseases – a national population study (Helena Canhão and Teresa Paiva)

33) DigiAdherence – supporting senior people at home (Rute de Sousa)

34) Releasing the power of users - articulating user interests to accelerate new innovative pathways in digital health and welfare sector. (Helena Canhão and Pedro Oliveira)

35) Exploiting Small-angle X-ray Scattering at ALBA to understand osteoporotic bone nanostructure and to enable the next generation of scaffolds for bone tissue generation. bl11 - NCD-SWEET, ALBA (Saba Abdulghani)

36) Grande Prémio Bial 2017 (Jaime Branco and Helena Canhão)

37) Saúde.Come – Promoting Food Security (Helena Canhão)

38) CoReumaPt_Osteoporose (mulheres com 65 anos de idade): CTOPRA - desenvolvimento e validação de um novo método imagiológico para prever o risco de fraturas osteoporótica (Ana Rodrigues)
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39) EpiReumaPt (Jaime Branco and Helena Canhão)
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40) Pharmacogenetics of Rheumatoid Arthritis (Helena Canhão)

Motivated investigators are encouraged to submit a research project proposal by sending the following form (project submission editable form) to rute.sousa(at)nms.unl.pt.



Scientific Papers






  • Vieira-Sousa E, Cavaleiro J, Mourão AF, Rodrigues AM, Albino-Teixeira A, Pimentel-Santos FM, Oliveira-Ramos F, Canhão H, Polido-Pereira J, Fonseca JE, Pereira da Silva JA, Romeu JC, Melo Gomes J, Costa L, Graça L, Leandro MJ, Santos MJ, Machado PM, Ramiro S. (2017) Acta Reumatológica Portuguesa: perspectives in 2017. Acta Reumatol Port. 2017 Apr-Jun;42(2):110-111.
  • Duarte AC, Santos-Faria D, Gonçalves MJ, Sepriano A, Mourão AF, Duarte C, Neves JS, Águeda AF, Ribeiro PÁ, Daniel A, Neto A, Cordeiro A, Rodrigues A, Barcelos A, Silva C, Ponte C, Vieira-Sousa E, Teixeira F, Oliveira-Ramos F, Araújo F, Barcelos F, Canhão H, Santos H, Ramos J, Pereira J, Costa J, Melo Gomes JA, Cunha-Miranda L, Costa L, Cerqueira M, Cruz M, Santos MJ, Bernardes M, Oliveira P, Abreu P, Figueira R, Barros R, Falcão S, Pinto P, Pimenta S, Capela S, Teixeira V, Fonseca JE. (2017) Portuguese recommendations for the use of methotrexate in rheumatic diseases - 2016 update. Acta Reumatol Port. 2017 May 9. [Epub ahead of print]
  • Duarte C, Sousa-Neves J, Águeda A, Ribeiro P, Daniel A, Eugénio G, Serra S, Araújo F, Barcelos A, Filipe B, Bernardes M, Canhão H, Cerqueira M, Capela S, Cordeiro A, Costa F, Costa L, Cruz M, Cunha Miranda L, Duarte C, Falcão S, Faria D, Figueira R, Freitas JP, Gonçalves MJ, Madruga Dias J, Melo Gomes J, Mourão AF, Neto A, Oliveira Ramos F, Pimenta S, Pinto P, Polido Pereira J, Ponte C, Ramos J, Rodrigues A, Santos H, Santos MJ, Sepriano A, Silva C, Tavares Costa J, Teixeira F, Teixeira V, Valente P, Vieira-Sousa E, Barros R, Abreu P, Fonseca J (2017) Portuguese Recommendations for the use of biological therapies in patients with rheumatoid arthritis- 2016 update. Acta Reumatol Port. 2017 May 4. [Epub ahead of print]
  • Chatzidionysiou K, Lie E, Lukina G, Hetland ML, Hauge EM, Pavelka K, Gabay C, Scherer A, Nordström D, Canhao H, Santos MJ, Tomsic M, Rotar Z, Hernández MV, Gomez-Reino J, Ancuta I, Kvien TK, van Vollenhoven R. (2017) Rituximab Retreatment in Rheumatoid Arthritis in a Real-life Cohort: Data from the CERERRA Collaboration. J Rheumatol. 2017 Jan 15. pii: jrheum.160460. doi: 10.3899/jrheum.160460. [Epub ahead of print]


  • Cui J, Diogo D, Stahl EA, Canhao H, Mariette X, Greenberg JD, Okada Y, Pappas DA, Fulton RS, Tak PP, Nurmohamed MT, Lee A, Larson DE, Kurreeman F, Deluca TL, O'Laughlin M, Fronick CC, Fulton LL, Mardis ER, van der Horst-Bruinsma IE, Wolbink GJ, Gregersen PK, Kremer JM, Crusius JB, de Vries N, Huizinga TW, Fonseca JE, Miceli-Richard C, Karlson EW, Coenen MJ, Barton A, Plenge RM, Raychaudhuri S. (2016) The role of rare protein-coding variants to anti-TNF treatment response in rheumatoid arthritis. Arthritis Rheumatol. 2016 Oct 27. doi: 10.1002/art.39966. PMID: 27788309
  • J Santos M, Canhão H, Faustino A, Fonseca JE. (2016) Reuma.pt - case study. Acta Med Port. 2016 Feb;29(2):83-4. doi: 10.20344/amp.7243. Epub 2016 Feb 29. No abstract available. PMID: 27234945


Mourão AF, Santos MJ, Melo Gomes JA, Martins FM, Mendonça SC, Oliveira Ramos F, Fernandes S, Salgado M, Guedes M, Carvalho S, Costa JA, Brito I, Duarte C, Furtado C, Lopes A, Rodrigues A, Sequeira G, Branco JC, Fonseca JE, Canhão H. Effectiveness and long-term retention of anti-tumour necrosis factor treatment in juvenile and adult patients with juvenile idiopathic arthritis: data from Reuma.pt. Rheumatology (Oxford). 2015 Dec 15. pii: kev398.

Vieira-Sousa E, Machado PM, Costa J, Ribeiro A, Aguiar R, Cerqueira M, Neto A, Bernardo A, Cordeiro A, Duarte C, Vinagre F, Canhão H, Santos H, Neves JS, Cunha-Miranda L, Silva M, Santos MJ, Bernardes M, Bogas M, Abreu P, Viana-Queiroz M, Barros R, Falcão S, Pimenta S, Teixeira V, Fonseca JE, Barcelos A; Portuguese Society of Rheumatology. PORTUGUESE RECOMMENDATIONS FOR THE USE OF BIOLOGICAL THERAPIES IN PATIENTS WITH PSORIATIC ARTHRITIS--2015 UPDATE. Acta Reumatol Port. 2015 Jul-Sep;40(3):275-90.

Laires PA, Gouveia M, Canhão H, Rodrigues A, Gouveia N, Eusébio M, Branco JC. Self-Reported Rheumatic Diseases and Early Retirement in Portugal. Value Health. 2015 Nov;18(7):A657. doi: 10.1016/j.jval.2015.09.2378. Epub 2015 Oct 20.

Laires PA, Gouveia M, Canhão H, Rodrigues A, Gouveia N, Eusébio M, Branco JC. Years of Working Life Lost Caused By Osteoarthritis In Portugal. Value Health. 2015 Nov;18(7):A642. doi: 10.1016/j.jval.2015.09.2294. Epub 2015 Oct 20.

Laires PA, Gouveia M, Canhão H, Rodrigues A, Gouveia N, Eusébio M, Branco JC. Years of Working Life Lost Caused By Rheumatic Diseases In Portugal. Value Health. 2015 Nov;18(7):A641. doi: 10.1016/j.jval.2015.09.2287. Epub 2015 Oct 20.

Laires PA, Gouveia M, Canhão H, Rodrigues A, Gouveia N, Eusébio M, Branco JC. Cost of Early Retirement Caused By Rheumatic Diseases In Portugal. Value Health. 2015 Nov;18(7):A641. doi: 10.1016/j.jval.2015.09.2289. Epub 2015 Oct 20.

Rodrigues A, Laires PA, Gouveia N, Eusébio M, Canhão H, Branco JC. Characterization of Osteoporosis In Portugal - Treatment Patterns And Reasons for Under-Treatment and Non-Persistence With Pharmacological Treatments. Value Health. 2015 Nov;18(7):A636-7. doi: 10.1016/j.jval.2015.09.2263. Epub 2015 Oct 20.

Finckh A, Neto D, Iannone F, Loza E, Lie E, van Riel P, Hetland ML, Pavelka K, Gottenberg JE, Canhão H, Mariette X, Turesson C. The impact of patient heterogeneity and socioeconomic factors on abatacept retention in rheumatoid arthritis across nine European countries. RMD Open. 2015 Apr 30;1(1):e000040. doi: 10.1136/rmdopen-2014-000040. eCollection 2015.

Mourão AF, Santos MJ, Mendonça S, Oliveira-Ramos F, Salgado M, Estanqueiro P, Melo-Gomes J, Martins F, Lopes A, Bettencourt BF, Bruges-Armas J, Costa J, Furtado C, Figueira R, Brito I, Branco J, Fonseca JE, Canhão H. Genetic Predictors of Poor Prognosis in Portuguese Patients with Juvenile Idiopathic Arthritis: Data from Reuma.pt. J Immunol Res. 2015;2015:706515. doi: 10.1155/2015/706515. Epub 2015 Oct 4.

Gabay C, Riek M, Hetland ML, Hauge EM, Pavelka K, Tomšič M, Canhao H, Chatzidionysiou K, Lukina G, Nordström DC, Lie E, Ancuta I, Hernández MV, van Riel PL, van Vollenhoven R, Kvien TK. Effectiveness of tocilizumab with and without synthetic disease-modifying antirheumatic drugs in rheumatoid arthritis: results from a European collaborative study. Ann Rheum Dis. 2015 Sep 15. pii: annrheumdis-2015-207760. doi: 10.1136/annrheumdis-2015-207760. [

Walker UA, Jaeger VK, Chatzidionysiou K, Hetland ML, Hauge EM, Pavelka K, Nordström DC, Canhão H, Tomšič M, van Vollenhoven R, Gabay C. Rituximab done: what's next in rheumatoid arthritis? A European observational longitudinal study assessing the effectiveness of biologics after rituximab treatment in rheumatoid arthritis. Rheumatology (Oxford). 2016 Feb;55(2):230-6. doi: 10.1093/rheumatology/kev297. Epub 2015 Aug 27.

Gouveia N, Rodrigues AM, Ramiro S, Machado P, da Costa LP, Mourão AF, Silva I, Rego T, Laires P, André R, Mauricio L, Romeu JC, Tavares V, Cerol J, Canhão H, Branco JC. EpiReumaPt: how to perform a national population based study - a practical guide. Acta Reumatol Port. 2015 Apr-Jun;40(2):128-36.

Rodrigues AM, Gouveia N, da Costa LP, Eusébio M, Ramiro S, Machado P, Mourão AF, Silva I, Laires P, Sepriano A, Araújo F, Coelho PS, Gonçalves S, Zhao A, Fonseca JE, de Almeida JM, Tavares V, da Silva JA, Barros H, Cerol J, Mendes J, Carmona L, Canhão H, Branco JC. EpiReumaPt- the study of rheumatic and musculoskeletal diseases in Portugal: a detailed view of the methodology. Acta Reumatol Port. 2015 Apr-Jun;40(2):110-24.

Branco JC, Canhão H. [EpiReumaPt - development and consequences]. Acta Reumatol Port. 2015 Apr-Jun;40(2):106-9. Portuguese. No abstract available. PMID: 26219964

Canet LM, Cáliz R, Lupiañez CB, Canhão H, Martinez M, Escudero A, Filipescu I, Segura-Catena J, Soto-Pino MJ, Ferrer MA, García A, Romani L, Pérez-Pampin E, González-Utrilla A, López Nevot MÁ, Collantes E, Fonseca JE, Sainz J. Genetic variants within immune-modulating genes influence the risk of developing rheumatoid arthritis and anti-TNF drug response: a two-stage case-control study. Pharmacogenet Genomics. 2015 Sep;25(9):432-43. doi: 10.1097/FPC.0000000000000155.

Romão VC, Santos MJ, Polido-Pereira J, Duarte C, Nero P, Miguel C, Costa JA, Bernardes M, Pimentel-Santos FM, Barcelos F, Costa L, Melo Gomes JA, Pereira da Silva JA, Cunha Branco J, Canas da Silva J, Pereira da Silva JA, Fonseca JE, Canhão H. Comparative Effectiveness of Tocilizumab and TNF Inhibitors in Rheumatoid Arthritis Patients: Data from the Rheumatic Diseases Portuguese Register, Reuma.pt. Biomed Res Int. 2015;2015:279890. doi: 10.1155/2015/279890. Epub 2015 Apr 27.

Marques A, Lourenço Ó, da Silva JA; Portuguese Working Group for the Study of the Burden of Hip Fractures in Portugal. The burden of osteoporotic hip fractures in Portugal: costs, health related quality of life and mortality. Osteoporos Int. 2015 Nov;26(11):2623-30. doi: 10.1007/s00198-015-3171-5. Epub 2015 May 19.

Gonçalves MJ, Sousa S, Inês LS, Cunha-Miranda L, Canhão H, Santos MJ. The weaker sex: Characterization of gender disparities in a nationwide lupus register (Reuma.pt/SLE). Joint Bone Spine. 2015 Oct;82(5):378-80. doi: 10.1016/j.jbspin.2015.01.004. Epub 2015 Apr 23. No abstract available. PMID: 25921914

Oliveira P, Zejnilovic L, Canhão H, von Hippel E. Innovation by patients with rare diseases and chronic needs. Orphanet J Rare Dis. 2015 Apr 9;10:41. doi: 10.1186/s13023-015-0257-2. PMID: 25887544

Canet LM, Filipescu I, Cáliz R, Lupiañez CB, Canhão H, Escudero A, Segura-Catena J, Soto-Pino MJ, Ferrer MA, García A, Romani L, Pérez-Pampin E, González-Utrilla A, López Nevot MA, Collantes E, Fonseca JE, Sainz Genetic variants within the TNFRSF1B gene and susceptibility to rheumatoid arthritis and response to anti-TNF drugs: a multicenter study. J. Pharmacogenet Genomics. 2015 Jul;25(7):323-33. doi: 10.1097/FPC.0000000000000140.

Diogo D, Bastarache L, Liao KP, Graham RR, Fulton RS, Greenberg JD, Eyre S, Bowes J, Cui J, Lee A, Pappas DA, Kremer JM, Barton A, Coenen MJ, Franke B, Kiemeney LA, Mariette X, Richard-Miceli C, Canhão H, Fonseca JE, de Vries N, Tak PP, Crusius JB, Nurmohamed MT, Kurreeman F, Mikuls TR, Okada Y, Stahl EA, Larson DE, Deluca TL, O'Laughlin M, Fronick CC, Fulton LL, Kosoy R, Ransom M, Bhangale TR, Ortmann W, Cagan A, Gainer V, Karlson EW, Kohane I, Murphy SN, Martin J, Zhernakova A, Klareskog L, Padyukov L, Worthington J, Mardis ER, Seldin MF, Gregersen PK, Behrens T, Raychaudhuri S, Denny JC, Plenge RM.
TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits. PLoS One. 2015 Apr 7;10(4):e0122271. doi: 10.1371/journal.pone.0122271. eCollection 2015.

Canhão H, Rodrigues AM, Santos MJ, Carmona-Fernandes D, Bettencourt BF, Cui J, Rocha FL, Canas Silva J, Polido-Pereira J, Pereira Silva JA, Costa JA, Araujo D, Silva C, Santos H, Duarte C, Cáliz R, Filipescu I, Pimentel-Santos F, Branco J, Sainz J, Plenge RM, Solomon DH, Bruges-Armas J, Da Silva JA, Fonseca JE, Karlson EW. TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthritis response to anti-tumor necrosis factor therapy. Biomed Res Int. 2015;2015:490295. doi: 10.1155/2015/490295. Epub 2015 Mar 5.

Laires PA, Canhão H, Gouveia M. Indirect costs associated with early exit from work attributable to rheumatic diseases. Eur J Public Health. 2015 Aug;25(4):677-82. doi: 10.1093/eurpub/cku241. Epub 2015 Jan 28.

Vidal B, Cascão R, Vale AC, Cavaleiro I, Vaz MF, Brito JA, Canhão H, Fonseca JE. Arthritis induces early bone high turnover, structural degradation and mechanical weakness. PLoS One. 2015 Jan 24;10(1):e0117100. doi: 10.1371/journal.pone.0117100. eCollection 2015. Erratum in: PLoS One. 2015;10(9):e0137372.

Inês L, Silva C, Galindo M, López-Longo FJ, Terroso G, Romão VC, Rúa-Figueroa I, Santos MJ, Pego-Reigosa JM, Nero P, Cerqueira M, Duarte C, Miranda LC, Bernardes M, Gonçalves MJ, Mouriño-Rodriguez C, Araújo F, Raposo A, Barcelos A, Couto M, Abreu P, Otón-Sanchez T, Macieira C, Ramos F, Branco JC, Silva JA, Canhão H, Calvo-Alén J; Rheumatic Diseases Registry of the Portuguese Society of Rheumatology; Registry of Systemic Lupus Erythematosus Patients of the Spanish Society of Rheumatology. Classification of Systemic Lupus Erythematosus: Systemic Lupus International Collaborating Clinics Versus American College of Rheumatology Criteria. A Comparative Study of 2,055 Patients From a Real-Life, International Systemic Lupus Erythematosus Cohort. Arthritis Care Res (Hoboken). 2015 Aug;67(8):1180-5. doi: 10.1002/acr.22539.

Kearsley-Fleet L, Závada J, Hetland ML, Nordström DC, Aaltonen KJ, Listing J, Zink A, Gati T, Rojkovich B, Iannone F, Gremese E, van Riel PL, van de Laar MA, Lie E, Kvien TK, Canhão H, Fonseca JE, Rotar Ž, Loza E, Carmona L, Askling J, Johansson K, Finckh A, Dixon WG, Hyrich KL; EULAR Study Group for Registers and Observational Drug Studies. The EULAR Study Group for Registers and Observational Drug Studies: comparability of the patient case mix in the European biologic disease modifying anti-rheumatic drug registers. Rheumatology (Oxford). 2015 Jun;54(6):1074-9. doi: 10.1093/rheumatology/keu446. Epub 2014 Nov 27.

Romão VC, Lima A, Bernardes M, Canhão H, Fonseca JE. Three decades of low-dose methotrexate in rheumatoid arthritis: can we predict toxicity? Immunol Res. 2014 Dec;60(2-3):289-310. doi: 10.1007/s12026-014-8564-6. Review.

Mourão AF, Santos MJ, Melo-Gomes J, Martins FM, Costa JA, Ramos F, Brito I, Duarte C, Figueira R, Figueiredo G, Furtado C, Lopes A, Oliveira M, Rodrigues A, Salgado M, Sousa M, Branco JC, Fonseca JE, Canhão H. Using the Juvenile Arthritis Disease Activity Score based on erythrocyte sedimentation rate or C-reactive protein level: results from the Portuguese register. Arthritis Care Res (Hoboken). 2014 Apr;66(4):585-91. doi: 10.1002/acr.22215.

Gonçalves MJ, Sousa S, Inês LS, Duarte C, Borges J, Silva C, Romão VC, Terroso G, Bernardes M, Cerqueira M, Raposo A, Sequeira G, Barcelos A, Macieira C, Canas da Silva J, Costa L, Pereira da Silva JA, Cunha-Miranda L, Da Silva JA, Canhão H, Santos MJ. Characterization of damage in Portuguese lupus patients: analysis of a national lupus registry. Lupus. 2015 Mar;24(3):256-62. doi: 10.1177/0961203314555172. Epub 2014 Oct 15.

Martins FM, da Silva JA, Santos MJ, Vieira-Sousa E, Duarte C, Santos H, Costa JA, Pimentel-Santos FM, Cunha I, Cunha Miranda L, Nóvoa T, Cruz M, Bernardes M, Araujo D, Pereira Silva JA, Silva JC, Branco JC, Gomes JA, Faustino A, Fonseca JE, Canhão H. DAS28, CDAI and SDAI cut-offs do not translate the same information: results from the Rheumatic Diseases Portuguese Register Reuma.pt. Rheumatology (Oxford). 2015 Feb;54(2):286-91. doi: 10.1093/rheumatology/keu313. Epub 2014 Aug 29.


EpiDoC Partners
Escola Nacional de Saúde Pública (ENSP)
Instituto de Tecnologia Química e Biológica (ITQB)

Statistics and Economics Analysis
NOVA IMS Information Management School: Pedro Simões Coelho; Jorge Mendes

Instituto de Saúde Pública da Universidade do Porto (ISPUP): Henrique de Barros; Raquel Lucas; Ana Cristina Santos
Norwegian University of Science and Technology (NTNU): Geir Espnes; Beate Andre; Kjersti Gronnning

Innovation & Health Economics
Catolica Lisbon School of Business and Economics (CLSBE): Pedro Oliveira; Leid Zejnilovic

Health Economics & Quality of Life Assessment
Faculdade de Economia da Universidade de Coimbra (FEUC) – Pedro Lopes Ferreira
NOVA School of Business and Economics (SBE) – Pedro Pitta Barros
Escola Nacional de Saúde Pública (ENSP) – Céu Mateus; Ana Moura; Julian Perelman; Rui Santana; Patricia Marques

Social & Human Sciences
Faculdade de Ciências Sociais e Humanas (FCSH UNL) – Paulo Machado

Medical Expertise
Faculdade de Medicina da Universidade de Coimbra (FMUC): José António Pereira da Silva
Faculdade de Medicina da Universidade de Lisboa (FMUL)
Sociedade Portuguesa de Reumatologia (SPR)
Direção Geral da Saúde (DGS)


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